Evidence map›Paper›PMID 32532087›Full record

ArticleNutrients2020

Attenuation of Lipopolysaccharide-Induced Acute Lung Injury by Hispolon in Mice, Through Regulating the TLR4/PI3K/Akt/mTOR and Keap1/Nrf2/HO-1 Pathways, and Suppressing Oxidative Stress-Mediated ER Stress-Induced Apoptosis and Autophagy.

Ching-Ying Huang, Jeng-Shyan Deng, Wen-Chin Huang, Wen-Ping Jiang, Guan-Jhong Huang

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers.

0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed
20.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

132 citing papers in PubMed, 272 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The Brown Strain ofInternational journal of molecular sciences · 2026
    Article
  6. Targeting mitochondrial apoptosis in septic lung injury: protective potential of omega-3 fatty acids.Apoptosis : an international journal on programmed cell death · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Natural Product Epipyrone A fromAntioxidants (Basel, Switzerland) · 2026
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Journal of microbiology and biotechnology · 2025
    Article
  19. Article
  20. Article

72 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ching-Ying HuangGraduate Institute of Aging Medicine, School of Medicine, China Medical University, Taichung 404, Taiwan.
Jeng-Shyan DengDepartment of Health and Nutrition Biotechnology, Asia University, Taichung 413, Taiwan.
Wen-Chin HuangGraduate Institute of Biomedical Sciences, School of Medicine, China Medical University, Taichung 404, Taiwan.
Wen-Ping JiangDepartment of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan.
Guan-Jhong HuangDepartment of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan.
China Medical University · TWAsia University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The anti-inflammatory effect of hispolon has identified it as one of the most important compounds from

Indexed as

Acute Lung InjuryAnimalsAnti-Inflammatory AgentsApoptosisAutophagyCatecholsEndoplasmic Reticulum Chaperone BiPEndoplasmic Reticulum StressHeme Oxygenase-1Kelch-Like ECH-Associated Protein 1LipopolysaccharidesMaleMembrane ProteinsMice, Inbred ICRNF-E2-Related Factor 2Oxidative StressAnti-Inflammatory AgentsCatecholsEndoplasmic Reticulum Chaperone BiPHeme Oxygenase-1hispolonHmox1 protein, mouseHspa5 protein, mouseKeap1 protein, mouseKelch-Like ECH-Associated Protein 1LipopolysaccharidesMembrane ProteinsmTOR protein, mouseNfe2l2 protein, mouseNF-E2-Related Factor 2Phosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktToll-Like Receptor 4TOR Serine-Threonine Kinasesanti-inflammationapoptosisER stresshispolonHO-1LPSNrf-2

Identifiers

PMID32532087
PMCPMC7352175
OpenAlexW3035217157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.