Evidence map›Paper›PMID 32532059›Full record

ArticleJournal of clinical medicine2020

Use of Antimalarial Agents is Associated with Favourable Physical Functioning in Patients with Systemic Lupus Erythematosus.

Alvaro Gomez, Sofia Soukka, Petter Johansson, Emil Åkerström, Sharzad Emamikia, Yvonne Enman, Katerina Chatzidionysiou, Ioannis Parodis

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00410384 phase3completednot on this map

A Phase 3, Multi-Center, Randomized, Double-Blind, Placebo-Controlled, 76-Week Study to Evaluate the Efficacy and Safety of Belimumab (HGS1006, LymphoStat-B™), a Fully Human Monoclonal Anti-BLyS Antibody, in Subjects With Systemic Lupus Erythematosus (SLE)

TypeinterventionalSponsorHuman Genome Sciences Inc.Ran2006 to 2010Enrolled819ConditionsSystemic Lupus ErythematosusArmsPlacebo, Belimumab 1 mg/kg, Belimumab 10 mg/kg
NCT00424476 phase3completednot on this map

A Phase 3, Multi-Center, Randomized, Double-Blind, Placebo-Controlled, 52-Wk Study to Evaluate the Efficacy and Safety of Belimumab (HGS1006, LymphoStat-B™), a Fully Human Monoclonal Anti-BLyS Antibody, in Subjects With Systemic Lupus Erythematosus (SLE)

TypeinterventionalSponsorHuman Genome Sciences Inc.Ran2007 to 2010Enrolled865ConditionsSystemic Lupus ErythematosusArmsPlacebo, Belimumab 1 mg/kg, Belimumab 10 mg/kg
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Alvaro GomezDivision of Rheumatology, Department of Medicine Solna, Karolinska Institutet, 171 76 Stockholm, Sweden.
Sofia SoukkaDivision of Rheumatology, Department of Medicine Solna, Karolinska Institutet, 171 76 Stockholm, Sweden.
Petter JohanssonDivision of Rheumatology, Department of Medicine Solna, Karolinska Institutet, 171 76 Stockholm, Sweden.
Emil ÅkerströmDivision of Rheumatology, Department of Medicine Solna, Karolinska Institutet, 171 76 Stockholm, Sweden.
Sharzad EmamikiaDivision of Rheumatology, Department of Medicine Solna, Karolinska Institutet, 171 76 Stockholm, Sweden.
Yvonne EnmanDivision of Rheumatology, Department of Medicine Solna, Karolinska Institutet, 171 76 Stockholm, Sweden.
Katerina ChatzidionysiouDivision of Rheumatology, Department of Medicine Solna, Karolinska Institutet, 171 76 Stockholm, Sweden.
Ioannis ParodisDivision of Rheumatology, Department of Medicine Solna, Karolinska Institutet, 171 76 Stockholm, Sweden.ORCID 0000-0002-4875-5395
Karolinska University Hospital · SE

Funding

GlaxoSmithKline PSS-212673-Karolinska-ISS-SAKarolinska Institutet -Reumatikerförbundet R-932236Stiftelsen Professor Nanna Svartz Fond 2019-00290Stockholms Läns Landsting -Ulla and Roland Gustafsson Foundation 2019-12
6 · The paper itself

Abstract

Impaired health-related quality of life (HRQoL) is a major problem in patients with systemic lupus erythematosus (SLE). Antimalarial agents (AMA) are the cornerstone of SLE therapy, but data on their impact on HRQoL are scarce. We investigated this impact using baseline data from the BLISS-52 (NCT00424476) and BLISS-76 (NCT00410384) trials (

Indexed as

antimalarial agentshealth perceptionshealth-related quality of lifemedication adherencepatient-reported outcomessystemic lupus erythematosustreatment

Identifiers

PMID32532059
PMCPMC7355692
OpenAlexW3034746363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.