Evidence map›Paper›PMID 32532036›Full record

SynthesisInternational journal of molecular sciences2020

Expression of MicroRNAs in Periodontal and Peri-Implant Diseases: A Systematic Review and Meta-Analysis.

Farah Asa'ad, Carlos Garaicoa-Pazmiño, Christer Dahlin, Lena Larsson

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 4 pooled it
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 4 syntheses or guidelines pooled it, 57 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Farah Asa'adDepartment of Biomaterials, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, SE-405 30 Göteborg, Sweden.ORCID 0000-0001-5186-2645
Carlos Garaicoa-PazmiñoDepartment of Periodontology, Oregon Health & Science University School of Dentistry, Portland, OR 97201, USA.ORCID 0000-0001-8486-6810
Christer DahlinDepartment of Biomaterials, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, SE-405 30 Göteborg, Sweden.
Lena LarssonDepartment of Periodontology, Institute of Odontology, University of Gothenburg, SE-405 30 Göteborg, Sweden.
University of Gothenburg · SENU Hospital Group · SEOregon Health & Science University · US

Funding

Osteology Foundation NARoyal Society of Arts and Sciences in Gothenburg (Kungliga Vetenskaps- och Vitterhets-Samhället i Göteborg) NA
6 · The paper itself

Abstract

aimThe purpose of this review was to evaluate the expression patterns of miRNAs in periodontal and peri-implant diseases, while identifying potential miRNAs with the greatest diagnostic ability as an oral fluid biomarker. MATERIALS AND

methodsHuman and animal studies were included when evaluating expression of miRNAs between health and different forms/stages of diseases, in which microarray and/or real-time polymerase chain reaction (RT-PCR) was carried out to detect fold changes in gene expression. After full-text analysis, 43 articles were considered for a qualitative assessment, and 16 miRNAs were selected to perform meta-analysis.

resultsBased on human studies, results showed an overall upregulation of most of the evaluated miRNAs in periodontitis, with miRNA-142-3p and miRNA-146a being the most conclusive on both microarray and RT-PCR values and potentially serving as diagnostic biomarkers for disease activity. Conversely, miR-155 was the only miRNA revealing a statistically significant difference (SSD) (

conclusionsAlthough our results revealed that a distinct differential expression of specific miRNAs can be noted between the state of health and disease, future research remains necessary to explore the functional role of specific miRNAs and their potential as therapeutic targets in periodontal and peri-implant diseases. MeSH Terms: periodontitis, peri-implantitis, epigenomics, microarray analysis, real-time polymerase chain reaction, microRNAs. CLINICAL RELEVANCE: Scientific background: Although most research identified different expression levels of miRNAs in periodontal and peri-implant diseases compared to their counterparts, their actual role in the pathogenesis of these conditions remains unclear. Therefore, we aimed to present a systematic review and meta-analysis on the expression patterns of miRNAs in periodontitis and peri-implantitis, while identifying potential miRNAs with the greatest diagnostic ability as an oral fluid biomarker. PRINCIPAL

findingsIn periodontitis-related studies, miRNA-142-3p and miRNA-146a were the most conclusive on both microarray and RT-PCR values. Scarce scientific evidence is available from peri-implant diseases. PRACTICAL IMPLICATIONS: Both miRNA-142-3p and miRNA-146a might serve as future diagnostic biomarkers for disease activity in periodontitis. Yet, future research remains necessary to explore the functional role of specific miRNAs and their potential as therapeutic targets in periodontal and peri-implant diseases.

Indexed as

AnimalsBiomarkersHumansMicroRNAsOligonucleotide Array Sequence AnalysisPeri-ImplantitisPeriodontitisBiomarkersMicroRNAsMIRN142 microRNA, humanMIRN146 microRNA, humanepigenomicsmicroarray analysismicroRNAsperi-implantitisperiodontitisreal-time polymerase chain reaction

Identifiers

PMID32532036
PMCPMC7312949
OpenAlexW3034379286

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.