SynthesisInternational journal of molecular sciences2020
Post-Traumatic Meningitis Is a Diagnostic Challenging Time: A Systematic Review Focusing on Clinical and Pathological Features.
Synthesis in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Can Hemorrhagic Stroke Genetics Help Forensic Diagnosis in Pediatric Age (<5 Years Old)?Genes · 2024Pooled it
- Glymphatic System a Window on TBI Pathophysiology: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Community-Acquired Pneumococcal Ventriculitis as a Complication of Otogenic Pneumococcal Meningitis: A Case Report.Case reports in infectious diseases · 2026Article
- Long-Term Outcomes of Adult Temporal Bone Fractures With Hearing Loss: Results of a Multinational Database Analysis.The Laryngoscope · 2025Article
- A Clinical Fallacy: Myth of Meningitis-Driven Dural Healing in Post-traumatic Cerebrospinal Fluid Leaks.Cureus · 2025Review
- Agricultural Farm-Related Head Injuries in Rural India: A Case Series.Korean journal of neurotrauma · 2025Article
- Developing practical machine learning survival models to identify high-risk patients for in-hospital mortality following traumatic brain injury.Scientific reports · 2025Article
- Facial high-pressure injection injury with air in a child.International journal of emergency medicine · 2024Article
- Article
- Sudden Death: A Practical Autopsy Approach to Unexplained Mediastinitis Due to Fatal Untreated Neck Infections-A Systematic Review.Diagnostics (Basel, Switzerland) · 2024Review
- Effect of Spontaneous Subarachnoid Hemorrhage on Cerebrospinal Fluid Indicators.Brain sciences · 2023Article
- The Expression of FOXO3a as a Forensic Diagnostic Tool in Cases of Traumatic Brain Injury: An Immunohistochemical Study.International journal of molecular sciences · 2023Article
- Endoscopic Endonasal Repair and Reconstruction of Traumatic Anterior Skull Base Defects.Case reports in otolaryngology · 2023Article
- Cervical spine injury: clinical and medico-legal overview.La Radiologia medica · 2023Review
- Liver Trauma: Management in the Emergency Setting and Medico-Legal Implications.Diagnostics (Basel, Switzerland) · 2022Review
- A Retrospective Study of Recurrent Bacterial Meningitis in Children: Etiology, Clinical Course, and Treatment.Computational and mathematical methods in medicine · 2022Article
- Steroid-Responsive Post-Traumatic Persistent Neutrophilic Meningitis.Case reports in medicine · 2022Article
- Traumatic brain injury: Estimate of the age of the injury based on neuroinflammation, endothelial activation markers and adhesion molecules.Histology and histopathology · 2021Review
- Pediatric Abusive Head Trauma: A Systematic Review.Diagnostics (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post-traumatic meningitis is a dreadful condition that presents additional challenges, in terms of both diagnosis and management, when compared with community-acquired cases. Post-traumatic meningitis refers to a meningeal infection causally related to a cranio-cerebral trauma, regardless of temporal proximity. The PICO (participants, intervention, control, and outcomes) question was as follows: "Is there an association between traumatic brain injury and post-traumatic meningitis?" The present systematic review was carried out according to the Preferred Reporting Items for Systematic Review (PRISMA) standards. Studies examining post-traumatic meningitis, paying particular attention to victims of traumatic brain injury, were included. Post-traumatic meningitis represents a high mortality disease. Diagnosis may be difficult both because clinical signs are nonspecific and blurred and because of the lack of pathognomonic laboratory markers. Moreover, these markers increase with a rather long latency, thus not allowing a prompt diagnosis, which could improve patients' outcome. Among all the detectable clinical signs, the appearance of cranial cerebrospinal fluid (CSF) leakage (manifesting as rhinorrhea or otorrhea) should always arouse suspicion of meningitis. On one hand, microbiological exams on cerebrospinal fluid (CSF), which represent the gold standard for the diagnosis, require days to get reliable results. On the other hand, radiological exams, especially CT of the brain, could represent an alternative for early diagnosis. An update on these issues is certainly of interest to focus on possible predictors of survival and useful tools for prompt diagnosis.
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