Evidence map›Paper›PMID 32532023›Full record

ReviewInternational journal of molecular sciences2020

Linking Biochemical and Structural States of SERCA: Achievements, Challenges, and New Opportunities.

Rodrigo Aguayo-Ortiz, L Michel Espinoza-Fonseca

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. P-type ATPase magnesium transporter MgtA acts as a dimer.Nature structural & molecular biology · 2025
    Article
  7. Article
  8. Article
  9. Inter-Organellar CaCells · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Mutational analysis of an antimalarial drug target,Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Review
  15. The molecular determinants of calcium ATPase inhibition by curcuminoids.Biochimica et biophysica acta. Biomembranes · 2024
    Article
  16. Article
  17. Article
  18. Isolation of the Sarcoplasmic Reticulum CaMethods and protocols · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rodrigo Aguayo-OrtizCenter for Arrhythmia Research, Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-9455-5397
L Michel Espinoza-FonsecaCenter for Arrhythmia Research, Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
University of Michigan · US

Funding

Hit-to-lead optimization for heart failure drug discoveryR01HL148068 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ESPINOZA-FONSECA, LENNANE MICHEL, HERRON, TODD JOSEPH · 2019 to 2022
$2.9M
Molecular mechanisms and regulation of the calcium pump in the heartR01GM120142 · NIGMS · UNIVERSITY OF MINNESOTA · PI ESPINOZA-FONSECA, LENNANE MICHEL · 2016 to 2020
$1.7M
Michigan Drug Discovery MDD2019202NHLBI NIH HHS R01 HL148068NHLBI NIH HHS R01HL148068NIGMS NIH HHS R01 GM120142NIGMS NIH HHS R01GM120142
6 · The paper itself

Abstract

Sarcoendoplasmic reticulum calcium ATPase (SERCA), a member of the P-type ATPase family of ion and lipid pumps, is responsible for the active transport of Ca

Indexed as

Adenosine TriphosphateAnimalsBinding SitesCrystallography, X-RayEnzyme InhibitorsHumansPhosphorylationProtein ConformationProtein DomainsSarcoplasmic Reticulum Calcium-Transporting ATPasesThapsigarginAdenosine TriphosphateEnzyme InhibitorsSarcoplasmic Reticulum Calcium-Transporting ATPasesThapsigarginbiophysical methodscalciuminhibitionmolecular simulationP-type ATPaseregulationSERCAX-ray crystallography

Identifiers

PMID32532023
PMCPMC7313052
OpenAlexW3035014526

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.