Evidence map›Paper›PMID 32531981›Full record

ArticleMaterials (Basel, Switzerland)2020

Quinoline‑ and Benzoselenazole-Derived Unsymmetrical Squaraine Cyanine Dyes: Design, Synthesis, Photophysicochemical Features and Light-Triggerable Antiproliferative Effects against Breast Cancer Cell Lines.

Eurico Lima, Renato E Boto, Diana Ferreira, José R Fernandes, Paulo Almeida, Luis F V Ferreira, Eliana B Souto, Amélia M Silva, Lucinda V Reis

Abstract read
In one paragraph

Article in Materials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eurico LimaChemistry Centre of Vila Real (CQ‑VR), University of Trás‑os‑Montes and Alto Douro, Quinta de Prados, 5001‑801 Vila Real, Portugal.ORCID 0000-0002-9402-8949
Renato E BotoHealth Sciences Research Centre (CICS‑UBI), University of Beira Interior, Av. Infante D. Henrique, 6201‑001 Covilhã, Portugal.ORCID 0000-0002-7256-2622
Diana FerreiraInstitute of Bioengineering and Biosciences (iBB), Higher Technical Institute, University of Lisbon, Av. Rovisco Pais, 1049‑001 Lisbon, Portugal.ORCID 0000-0002-7862-4687
José R FernandesChemistry Centre of Vila Real (CQ‑VR), University of Trás‑os‑Montes and Alto Douro, Quinta de Prados, 5001‑801 Vila Real, Portugal.
Paulo AlmeidaHealth Sciences Research Centre (CICS‑UBI), University of Beira Interior, Av. Infante D. Henrique, 6201‑001 Covilhã, Portugal.
Luis F V FerreiraInstitute of Bioengineering and Biosciences (iBB), Higher Technical Institute, University of Lisbon, Av. Rovisco Pais, 1049‑001 Lisbon, Portugal.
Eliana B SoutoDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal.
Amélia M SilvaDepartment of Biology and Environment (DeBA), and Centre for Research and Technology of Agro‑Environmental and Biological Sciences (CITAB‑UTAD), University of Trás‑os‑Montes and Alto Douro, Quinta de Prados, 5001‑801 Vila Real, Portugal.ORCID 0000-0002-7524-9914
Lucinda V ReisChemistry Centre of Vila Real (CQ‑VR), University of Trás‑os‑Montes and Alto Douro, Quinta de Prados, 5001‑801 Vila Real, Portugal.ORCID 0000-0001-5654-9359

Funding

FEDER/COMPETE/POCI POCI-01-0145-FEDER-006958FEDER/COMPETE/POCI POCI-01-0145-FEDER-007491Fundação para a Ciência e a Tecnologia M-ERA-NET/0002/2015Fundação para a Ciência e a Tecnologia SFRH/BD/147645/2019Fundação para a Ciência e a Tecnologia UIDB/ 00616/2020 (CQ-VR)Fundação para a Ciência e a Tecnologia UIDB/ 04033/2020 (CITAB)Fundação para a Ciência e a Tecnologia UID/Multi/00709/2019Fundação para a Ciência e a Tecnologia UID/NAN/50024/2019
6 · The paper itself

Abstract

Photodynamic therapy is an innovative treatment approach broadly directed towards oncological diseases. Its applicability and efficiency are closely related to the interaction of three main components, namely a photosensitizer, light and molecular triplet oxygen, which should drive cell death. Recently, several studies have demonstrated that squaraine cyanine dyes have a set of photophysical and photochemical properties that have made of these compounds' potential photosensitizers for this therapeutic modality. In the present research work, we describe the synthesis and characterization of four quinoline‑ and benzoselenazole‑derived unsymmetrical squaraine cyanine dyes. Except for the precursor of aminosquaraine dyes, i.e.,

Indexed as

benzoselenazolebreast cancerlight‑stabilityphototherapeutic effectsquinolinesinglet oxygenunsymmetrical squaraine dyes

Identifiers

PMID32531981
PMCPMC7321604

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.