Evidence map›Paper›PMID 32531970›Full record

ArticleCancers2020

The Clinicopathological Features and Genetic Alterations in Epstein-Barr Virus-Associated Gastric Cancer Patients after Curative Surgery.

Wen-Liang Fang, Ming-Huang Chen, Kuo-Hung Huang, Chien-Hsing Lin, Yee Chao, Su-Shun Lo, Anna Fen-Yau Li, Chew-Wun Wu, Yi-Ming Shyr

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
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  4. Relationship betweenWorld journal of clinical oncology · 2025
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  10. Immunoprofile of adenosquamous carcinoma in gastric cancer.Journal of the Chinese Medical Association : JCMA · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Wen-Liang FangDivision of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei 11217, Taiwan.
Ming-Huang ChenDepartment of Surgery, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan.
Kuo-Hung HuangDivision of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei 11217, Taiwan.ORCID 0000-0002-5388-8117
Chien-Hsing LinGenome Research Center, National Yang-Ming University, Taipei 11221, Taiwan.
Yee ChaoDepartment of Surgery, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan.
Su-Shun LoDepartment of Surgery, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan.
Anna Fen-Yau LiDepartment of Surgery, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan.
Chew-Wun WuDivision of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei 11217, Taiwan.
Yi-Ming ShyrDivision of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei 11217, Taiwan.
National Yang Ming Chiao Tung University · TW

Funding

Ministry of Science and Technology, Taiwan 107-2314-B-075 -007
6 · The paper itself

Abstract

backgroundEpstein-Barr virus (EBV)-associated gastric cancer (GC) is one of four major gastric cancer types and is traditionally considered to be related to lymphoepithelioma-like GC. Few studies have investigated the clinical significance of EBV infection in intestinal/solid type, diffuse (poorly cohesive) type, and lymphoepithelioma-like GC.

methodsA total of 460 GC patients receiving curative surgery were enrolled. The clinicopathological features, genetic alterations and prognoses were compared between patients with and without EBV infection.

resultsEBV-positive GC patients (

conclusionsIntestinal/solid type GC patients with EBV-positive tumors were associated with higher PD-L1 expression and more liver metastases, while lymphoepithelioma-like GC patients with EBV-positive tumors had more PI3K/AKT pathway mutations. Immunotherapy and targeted therapy may be beneficial for these groups of patients. Routine EBV survey is recommended in GC.

Indexed as

Epstein–Barr virusimmunotherapyintestinal/solidlymphoepithelioma-likePD-L1poorly cohesivetargeted therapy

Identifiers

PMID32531970
PMCPMC7352714
OpenAlexW3034195050

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.