Evidence map›Paper›PMID 32531952›Full record

ArticleCells2020

Induction of the Endoplasmic-Reticulum-Stress Response: MicroRNA-34a Targeting of the IRE1α-Branch.

Lena Krammes, Martin Hart, Stefanie Rheinheimer, Caroline Diener, Jennifer Menegatti, Friedrich Grässer, Andreas Keller, Eckart Meese

Abstract read
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Deciphering the Link Between ERFrontiers in aging neuroscience · 2022
    Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lena KrammesInstitute of Human Genetics, Saarland University, 66421 Homburg, Germany.
Martin HartInstitute of Human Genetics, Saarland University, 66421 Homburg, Germany.
Stefanie RheinheimerInstitute of Human Genetics, Saarland University, 66421 Homburg, Germany.
Caroline DienerInstitute of Human Genetics, Saarland University, 66421 Homburg, Germany.
Jennifer MenegattiInstitute of Virology, Saarland University, 66421 Homburg, Germany.
Friedrich GrässerInstitute of Virology, Saarland University, 66421 Homburg, Germany.
Andreas KellerChair for Clinical Bioinformatics, Saarland University, 66123 Saarbrücken, Germany.
Eckart MeeseInstitute of Human Genetics, Saarland University, 66421 Homburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD) are characterized by the accumulation of misfolded proteins in the endoplasmic reticulum (ER) and the unfolded protein response (UPR). Modulating the UPR is one of the major challenges to counteract the development of neurodegenerative disorders and other diseases with affected UPR. Here, we show that miR-34a-5p directly targets the IRE1α branch of the UPR, including the genes

Indexed as

Endoplasmic Reticulum StressEndoribonucleasesHumansMicroRNAsProtein Serine-Threonine KinasesTransfectionUnfolded Protein ResponseEndoribonucleasesERN1 protein, humanMicroRNAsMIRN34 microRNA, humanProtein Serine-Threonine KinasesBIPendoplasmic reticulumIRE1αmiR-34a-5pneurodegenerationunfolded protein responseXBP1

Identifiers

PMID32531952
PMCPMC7348704

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.