ArticleMolecules (Basel, Switzerland)2020
In Vitro Metabolic Transformation of Pharmaceuticals by Hepatic S9 Fractions from Common Carp
Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
- The threat of pollutants mixtures on freshwater fishes in Sri Lankan lotic ecosystems under changing climate: a review of current status and future research perspective.Frontiers in physiology · 2026Review
- Comparative Toxicokinetics and Biomarker Responses of Typical Psychiatric Pharmaceuticals inToxics · 2025Article
- Development of a method for assessing the accumulation and metabolization of antidepressant drugs in zebrafish (Danio rerio) eleutheroembryos.Analytical and bioanalytical chemistry · 2021Article
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Authors and funding
7 authors at 2 institutions in 4 countries.
Funding
Abstract
Water from wastewater treatment plants contains concentrations of pharmaceutically active compounds as high as micrograms per liter, which can adversely affect fish health and behavior, and contaminate the food chain. Here, we tested the ability of the common carp hepatic S9 fraction to produce the main metabolites from citalopram, metoprolol, sertraline, and venlafaxine. Metabolism in fish S9 fractions was compared to that in sheep. The metabolism of citalopram was further studied in fish. Our results suggest a large difference in the rate of metabolites formation between fish and sheep. Fish hepatic S9 fractions do not show an ability to form metabolites from venlafaxine, which was also the case for sheep. Citalopram, metoprolol, and sertraline were metabolized by both fish and sheep S9. Citalopram showed concentration-dependent
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