Evidence map›Paper›PMID 32531919›Full record

ArticlePharmaceuticals (Basel, Switzerland)2020

Brain-Selective Estrogen Therapy Prevents Androgen Deprivation-Associated Hot Flushes in a Rat Model.

Istvan Merchenthaler, Malcolm Lane, Christina Stennett, Min Zhan, Vien Nguyen, Katalin Prokai-Tatrai, Laszlo Prokai

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Istvan MerchenthalerDepartment of Epidemiology and Public Health, University of Maryland, Baltimore, MD 21201, USA.
Malcolm LaneDepartment of Epidemiology and Public Health, University of Maryland, Baltimore, MD 21201, USA.
Christina StennettDepartment of Epidemiology and Public Health, University of Maryland, Baltimore, MD 21201, USA.
Min ZhanDepartment of Epidemiology and Public Health, University of Maryland, Baltimore, MD 21201, USA.
Vien NguyenDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
Katalin Prokai-TatraiDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.ORCID 0000-0001-5595-1346
Laszlo ProkaiDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.ORCID 0000-0002-4559-3458
University of Maryland, Baltimore · USUniversity of North Texas · US

Funding

EXPAND PARTICIPATION BY MINORITIES IN BIOMEDICAL SCIENCER25GM055036 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI SUMMERS, MICHAEL FINLEY · 1996 to 2021
$16.9M
RESEARCH TRAINING IN THE EPIDEMIOLOGY OF AGINGT32AG000262 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI ANN L GRUBER-BALDINI, DENISE L ORWIG · 1998 to 2026
$8.2M
Brain-Selective Therapy to Alleviate Hot Flushes of Prostate Cancer PatientsR01CA215550 · NCI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI MERCHENTHALER, ISTVAN JOZSEF, PROKAI, LASZLO · 2017 to 2019
$1.0M
NCI NIH HHS R01 CA215550NIA NIH HHS T32 AG000262NIGMS NIH HHS R25 GM055036NIH HHS CA215550, CA195910Welch Foundation BK-0031
6 · The paper itself

Abstract

Hot flushes are best-known for affecting menopausal women, but men who undergo life-saving castration due to androgen-sensitive prostate cancer also suffer from these vasomotor symptoms. Estrogen deficiency in these patients is a direct consequence of androgen deprivation, because estrogens (notably 17β-estradiol, E

Indexed as

androgen deprivationbrain-selective estrogen prodrugDHEDmale hot flushprostate cancerrat modelthermoregulation

Identifiers

PMID32531919
PMCPMC7344942
OpenAlexW3034593707

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.