Observational studyJournal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus2020
Ocular manifestations and viral shedding in tears of pediatric patients with coronavirus disease 2019: a preliminary report.
Observational study in Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 4 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Ocular transmission and manifestation for coronavirus disease: a systematic review.International health · 2022Pooled it
- Pooled Prevalence Estimate of Ocular Manifestations in COVID-19 Patients: A Systematic Review and Meta-Analysis.Iranian journal of medical sciences · 2022Pooled it
- Children's role in the COVID-19 pandemic: a systematic review of early surveillance data on susceptibility, severity, and transmissibility.Scientific reports · 2021Pooled it
- Ocular manifestations in COVID-19 patients: A systematic review and meta-analysis.Travel medicine and infectious diseasePooled it
- SARS-CoV-2 positivity rates in tear secretions of inpatient COVID-positive individuals in an Indian tertiary care setting.Indian journal of ophthalmology · 2025Article
- Ocular Lesions Related to COVID-19 and Its Vaccines.Journal of ophthalmology · 2025Review
- Ocular neuroinflammatory response secondary to SARS-CoV-2 infection-a review.Frontiers in immunology · 2025Review
- Isolated Depo-Medrol Administration under Tenon's Capsule for Post-COVID-19 Uveitis in a Child: A Case Report and Literature Review.Journal of clinical medicine · 2024Article
- Gastrointestinal and Hepatic Manifestations of COVID-19 in Children: A Systematic Review and Meta-analysis.Acta medica Philippina · 2024Article
- Incidence and clinical characteristic of ocular surface manifestation: an evaluation of conjunctival swab results in Corona Virus 2019 (COVID-19) patients in Jakarta, Indonesia.Journal of ophthalmic inflammation and infection · 2023Article
- Acute and sub-acute ocular manifestations in pediatric patients with COVID-19: A systematic review.Medical hypothesis, discovery & innovation ophthalmology journal · 2022Review
- Ophthalmological findings in patients suspected with COVID-19 at a tertiary hospital in Pernambuco, Brazil.Arquivos brasileiros de oftalmologia · 2022Article
- COVID-19 case presented initially with keratoconjunctivitis: A case report.Annals of medicine and surgery (2012) · 2021Article
- SARS-CoV-2 in Conjunctiva and Tears and Ocular Symptoms of Patients with COVID-19.Vision (Basel, Switzerland) · 2021Article
- SARS-CoV-2 and the Eyes: A Review of the Literature on Transmission, Detection, and Ocular Manifestations.Medical science monitor : international medical journal of experimental and clinical research · 2021Review
- COVID-19 Ocular Prophylaxis: The Potential Role of Ozonated-Oils in Liposome Eyedrop Gel.Translational vision science & technology · 2021Article
- Ophthalmia neonatorum as the presenting sign of SARS-CoV-2.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2021Article
- In the eye of the storm: SARS-CoV-2 infection and replication at the ocular surface?Stem cells translational medicine · 2021Review
- Ophthalmic manifestations associated with SARS-CoV-2 in newborn infants: a preliminary report.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2021Article
- Retinopathy of prematurity screening and risk mitigation during the COVID-19 pandemic.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2021Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate ocular manifestations and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) prevalence in the tears of children with coronavirus disease 2019 (COVID-19).
methodsA total of 27 pediatric patients with confirmed COVID-19 infection hospitalized from March 16 to April 15, 2020, at the Bambino Gesù Children's Hospital were enrolled in the study. At admission, all patients showed ocular manifestations. Reverse transcriptase-polymerase chain reaction from nasopharyngeal and conjunctival swabs were performed every 2-3 days before discharge.
resultsOf the 27 patients, 4 (15%) were asymptomatic, 15 (56%) showed respiratory symptoms, and 8 (30%) had gastrointestinal symptoms. At admission, nasopharyngeal swabs were positive for COVID-19 in all patients; on the second swabs, 7 children (26%) tested negative, and 20 remained positive for COVID-19. Ocular manifestations consistent with mild viral conjunctivitis were observed in 4 patients (15%). At first conjunctival swab, 3 patients (11%), 1 symptomatic and 2 asymptomatic for ocular infection, had positive findings for COVID-19; 2 became negative on the second test and 1 on the third.
conclusionsIn our study cohort, ocular manifestations of COVID-19 seem to have had a milder clinical course in pediatric patients than in adults. Despite the low prevalence and rapid regression of viral presence in the conjunctiva, SARS-CoV-2 transmission through tears may be possible, even in patients without apparent ocular involvement.
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