Evidence map›Paper›PMID 32531337›Full record

ArticleNanomedicine : nanotechnology, biology, and medicine2020

Ion channel formation by N-terminally truncated Aβ (4-42): relevance for the pathogenesis of Alzheimer's disease.

Abhijith G Karkisaval, Agueda Rostagno, Rustam Azimov, Deependra K Ban, Jorge Ghiso, Bruce L Kagan, Ratnesh Lal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomedicine : nanotechnology, biology, and medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Abhijith G KarkisavalDepartment of Mechanical and Aerospace Engineering, University of California San Diego, La Jolla, California, 92092, USA.
Agueda RostagnoDepartment of Pathology, New York University Grossman School of Medicine, 550 First Avenue, New York, NY, 10016, USA.
Rustam AzimovDepartment of Psychiatry, Geffen School of Medicine, University of California, Los Angeles, California 90095, USA; Semel Neuropsychiatric for Neuroscience & Human Behavior, University of California, Los Angeles, California 90095, United States.
Deependra K BanDepartment of Mechanical and Aerospace Engineering, University of California San Diego, La Jolla, California, 92092, USA.
Jorge GhisoDepartment of Pathology, New York University Grossman School of Medicine, 550 First Avenue, New York, NY, 10016, USA; Department of Psychiatry, New York University Grossman School of Medicine, 550 First Avenue, New York, NY, 10016, USA. Electronic address: jorge.ghiso@nyulangone.org.
Bruce L KaganDepartment of Psychiatry, Geffen School of Medicine, University of California, Los Angeles, California 90095, USA; Semel Neuropsychiatric for Neuroscience & Human Behavior, University of California, Los Angeles, California 90095, United States. Electronic address: bkagan@mednet.ucla.edu.
Ratnesh LalDepartment of Mechanical and Aerospace Engineering, University of California San Diego, La Jolla, California, 92092, USA; Department of Bioengineering, University of California San Diego, La Jolla, California, 92092, USA; Materials Science and Engineering, University of California San Diego, La Jolla, California, 92092, USA. Electronic address: rlal@eng.ucsd.edu.

Funding

Relevance of Abeta N-terminal Truncations for Alzheimer Pathogenesis and Therapy - Resubmission - 1RF1AG059695 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GHISO, JORGE A · 2019 to 2019
$3.7M
Amyloid ion channels to design therapeutics for neurodegenerative diseasesR01AG028709 · NIA · UNIVERSITY OF CHICAGO · PI LAL, RATNESHWAR · 2006 to 2018
$3.6M
Cerebral Amyloidosis and DementiaR01AG030539 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GHISO, JORGE A · 2009 to 2013
$2.2M
Designing array-AFM to study cellular interactions mediating transmission and progression of AD pathophysiology in brainR56AG058069 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LAL, RATNESHWAR · 2018 to 2019
$755k
Insights into the Brain Clearance Mechanisms of Oligomeric Beta-Amyloid SpeciesR21AG051266 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GHISO, JORGE A · 2015 to 2016
$466k
iPSC from British and Danish dementias: new discovery tools for brain amyloidosesR21AG044817 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BUSCIGLIO, JORGE A, GHISO, JORGE A · 2013 to 2014
$463k
NIA NIH HHS R01 AG028709NIA NIH HHS R01 AG030539NIA NIH HHS R21 AG044817NIA NIH HHS R21 AG051266NIA NIH HHS R56 AG058069NIA NIH HHS RF1 AG059695
6 · The paper itself

Abstract

Aβ deposition is a pathological hallmark of Alzheimer's disease (AD). Besides the full-length amyloid forming peptides (Aβ

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAntibodies, MonoclonalBrainHumansIon ChannelsMicroscopy, Atomic ForcePeptide FragmentsProtein Conformation, beta-StrandAmyloid beta-Peptidesamyloid beta-protein (1-40)Antibodies, MonoclonalIon ChannelsPeptide FragmentsAmyloidElectrophysiologyOligomersTruncated Aβ peptides

Identifiers

PMID32531337
PMCPMC8132454

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.