ArticleBehavioural brain research2020
Touchscreen-based assessment of risky-choice in mice.
Article in Behavioural brain research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Risk reshapes amygdala representation of choice.bioRxiv : the preprint server for biology · 2025Article
- Integrating optical neuroscience tools into touchscreen operant systems.Nature protocols · 2025Review
- Animal Welfare, Agency, and Animal-Computer Interaction.Animals : an open access journal from MDPI · 2025Article
- Maximising translational value of the Iowa gambling task in preclinical studies through the use of the rodent touchscreen.Frontiers in psychiatry · 2025Review
- Article
- Divergent risky decision-making and impulsivity behaviors in Lewis rat substrains with low genetic difference.Behavioral neuroscience · 2023Article
- Visiomode: An open-source platform for building rodent touchscreen-based behavioral assays.Journal of neuroscience methods · 2023Article
- Advances in understanding meso-cortico-limbic-striatal systems mediating risky reward seeking.Journal of neurochemistry · 2021Review
- Reward/Punishment-Based Decision Making in Rodents.Current protocols in neuroscience · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Addictions are characterized by choices made to satisfy the addiction despite the risk it could produce an adverse consequence. Here, we developed a murine version of a 'risky decision-making' task (RDT), in which mice could respond on a touchscreen panel to obtain either a large milkshake reward associated with varying probability of footshock, or a smaller amount of the same reward that was never punished. Results showed that (the following font is incorrectly smaller/subscripted) mice shifted choice from the large to small reward stimulus as shock probability increased. Immunohistochemical analysis revealed more Fos-positive cells in prelimbic cortex (PL) and basal amygdala (BA) after RDT testing, and a strong anti-correlation between infralimbic cortex (IL) activity and choice of the large reward stimulus under likely (75-100 % probability) punishment. These findings establish an assay for risky choice in mice and provide preliminary insight into the underlying neural substrates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.