Evidence map›Paper›PMID 32531146›Full record

SynthesisBJOG : an international journal of obstetrics and gynaecology2020

Maternal transmission of SARS-COV-2 to the neonate, and possible routes for such transmission: a systematic review and critical analysis.

K F Walker, K O'Donoghue, N Grace, J Dorling, J L Comeau, W Li, J G Thornton

Registry-linked trialAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BJOG : an international journal of obstetrics and gynaecology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05175755 (Genetic Risk Factors Predictive of the Occurrence of Maternally Diagnosed Perinatal Depression in Women), which is not on this map. Cited by 135 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
135citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05175755 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Genetic Risk Factors Predictive of the Occurrence of Maternally Diagnosed Perinatal Depression in Women

TypeinterventionalSponsorFondation Hôpital Saint-JosephRan2023 to 2024Enrolled3,000ConditionsPerinatal DepressionArmsPatients
3 · Its place in the literature

Who cites it

135 citing papers in PubMed, 14 syntheses or guidelines pooled it.

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  7. Vertical Transmission of SARS-CoV-2: A Systematic Review.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2021
    Pooled it
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  10. Impact of COVID-19 on Pregnancy.International journal of medical sciences · 2021
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75 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

K F WalkerDivision of Child Health, Obstetrics and Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK.ORCID 0000-0001-5794-7324
K O'DonoghueThe Irish Centre for Maternal and Child Health, Cork University Maternity Hospital, University College Cork, Cork, Ireland.
N GraceSchool of English, University of Nottingham, Nottingham, UK.ORCID 0000-0002-8543-1162
J DorlingDepartment of Pediatrics, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.
J L ComeauDepartment of Pediatrics, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.
W LiDepartment of Obstetrics and Gynaecology, Monash University, Clayton, Vic., Australia.
J G ThorntonDivision of Child Health, Obstetrics and Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK.ORCID 0000-0001-9764-6876

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEarly reports of COVID-19 in pregnancy described management by caesarean, strict isolation of the neonate and formula feeding. Is this practice justified?

objectiveTo estimate the risk of the neonate becoming infected with SARS-CoV-2 by mode of delivery, type of infant feeding and mother-infant interaction. SEARCH STRATEGY: Two biomedical databases were searched between September 2019 and June 2020. SELECTION CRITERIA: Case reports or case series of pregnant women with confirmed COVID-19, where neonatal outcomes were reported. DATA COLLECTION AND ANALYSIS: Data were extracted on mode of delivery, infant infection status, infant feeding and mother-infant interaction. For reported infant infection, a critical analysis was performed to evaluate the likelihood of vertical transmission. MAIN

resultsForty nine studies included information on mode of delivery and infant infection status for 655 women and 666 neonates. In all, 28/666 (4%) tested positive postnatally. Of babies born vaginally, 8/292 (2.7%) tested positivecompared with 20/374 (5.3%) born by Caesarean. Information on feeding and baby separation were often missing, but of reported breastfed babies 7/148 (4.7%) tested positive compared with 3/56 (5.3%) for reported formula fed ones. Of babies reported as nursed with their mother 4/107 (3.7%) tested positive, compared with 6/46 (13%) for those who were reported as isolated.

conclusionsNeonatal COVID-19 infection is uncommon, rarely symptomatic, and the rate of infection is no greater when the baby is born vaginally, breastfed or remains with the mother. TWEETABLE ABSTRACT: Risk of neonatal infection with COVID-19 by delivery route, infant feeding and mother-baby interaction.

Indexed as

Infant FormulaBetacoronavirusBottle FeedingBreast FeedingBreast Milk ExpressionCesarean SectionChinaCoronavirus InfectionsCOVID-19Delivery, ObstetricFemaleHumansInfant, NewbornInfectious Disease Transmission, VerticalMilk, HumanMother-Child Relationsartificial feedingbirthbreast-feedingcaesareanCOVID-19disambiguationduplicate publicationisolationneonatal infectionpregnancySARS-COV-2

Identifiers

PMID32531146
PMCPMC7323034

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.