ArticlePloS one2020
Peripheral circadian rhythms in the liver and white adipose tissue of mice are attenuated by constant light and restored by time-restricted feeding.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 40 citations in OpenAlex.
- Circadian rhythms in pediatric neurocritical care: interfaces and opportunities.Frontiers in neurology · 2026Review
- Exposure to heavy metals and trace elements and risk of dyslipidemia: a nested case-control analysis in rural adults.Frontiers in endocrinology · 2026Article
- Circadian regulation of gastrointestinal motility and the effect on disorders of gut-brain interaction.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2026Review
- Dissociation between subjective sleep quality and lipid dysregulation in underground miners: night shift work as an independent risk factor for hypercholesterolemia.Frontiers in public health · 2026Article
- Frequent Shifts During Chronic Jet Lag Uncouple Liver Rhythms From the Light Cycle in Male Mice.Journal of biological rhythms · 2025Article
- Mistimed Feeding Disrupts Metabolic Rhythm and Increases Lipid Accumulation of Growing Rabbits in Winter.Animals : an open access journal from MDPI · 2025Article
- Impact of an extended light regimen imposed during nursery period on the performance and lipid metabolism of weanling pigs.Animal bioscience · 2025Article
- Peripheral clocks and systemicFrontiers in endocrinology · 2025Review
- Article
- Circadian Disruption across Lifespan Impairs Glucose Homeostasis and Insulin Sensitivity in Adult Mice.Metabolites · 2024Article
- Fasting: From Physiology to Pathology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Time-Restricted Feeding Could Not Reduce Rainbow Trout Lipid Deposition Induced by Artificial Night Light.Metabolites · 2022Article
- Regulation of Circadian Genes Nr1d1 and Nr1d2 in Sex-Different Manners during Liver Aging.International journal of molecular sciences · 2022Article
- A new apparatus to analyze meal-related ingestive behaviors in rats fed a complex multi-food diet.Physiology & behavior · 2022Article
- Nutrients and the Circadian Clock: A Partnership Controlling Adipose Tissue Function and Health.Nutrients · 2022Review
- Circadian rhythms of the mRNA abundances of clock genes and glucose transporters in the jejunum of weanling-growing pigs.Veterinary medicine and science · 2022Article
- Assessing temporal eating pattern in free living humans through the myCircadianClock app.International journal of obesity (2005) · 2022Review
- Different levels of circadian (de)synchrony -- where does it hurt?F1000Research · 2022Review
- Circadian autophagy drives iTRF-mediated longevity.Nature · 2021Article
- Mathematical modeling of mammalian circadian clocks affecting drug and disease responses.Journal of pharmacokinetics and pharmacodynamics · 2021Review
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Disturbance of circadian rhythms underlies various metabolic diseases. Constant light exposure (LL) is known to disrupt both central and peripheral circadian rhythms. Here, we attempted to determine whether the effects of LL are different between various peripheral tissues and whether time-restricted feeding restores the circadian rhythms especially in white adipose tissue (WAT). Six-week-old mice were subjected to three feeding regimes: ad libitum feeding under light/dark phase (LD), ad libitum feeding under LL cycle, and restricted feeding at night-time under LL cycle with a normal chow. After 3 weeks, we compared body weight, food intake, plasma levels of lipids and glucose, and the expression patterns of the clock genes and the genes involved in lipid metabolism in the liver and WAT. The mice kept under LL with or without time-restricted feeding were 5.2% heavier (p<0.001, n = 16) than the mice kept under LD even though the food intakes of the two groups were the same. Food intake occurred mostly in the dark phase. LL disrupted this pattern, causing disruptions in circadian rhythms of plasma levels of triglycerides (TG) and glucose. Time-restricted feeding partially restored the rhythms. LL eliminated the circadian rhythms of the expression of the clock genes as well as most of the genes involved in lipid metabolism in both liver and WAT. More notably, LL markedly decreased not only the amplitude but also the average levels of the expression of the genes in the liver, but not in the WAT, suggesting that transcription in the liver is sensitive to constant light exposure. Time-restricted feeding restored the circadian rhythms of most of the genes to various degrees in both liver and WAT. In conclusion, LL disrupted the peripheral circadian rhythms more severely in liver than in WAT. Time-restricted feeding restored the circadian rhythms in both tissues.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.