ArticlePLoS medicine2020
Fatty acids in the de novo lipogenesis pathway and incidence of type 2 diabetes: A pooled analysis of prospective cohort studies.
Open access · goldAbstract read
In one paragraph
Article in PLoS medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 69 citations in OpenAlex.
- Metabolomic insights into maternal and neonatal complications in pregnancies affected by type 1 diabetes.Diabetologia · 2023Trial
- Altered Lipid Metabolism in Obese Women With Gestational Diabetes and Associations With Offspring Adiposity.The Journal of clinical endocrinology and metabolism · 2022Trial
- Circulating palmitoleic acid is associated with cerebral glucose metabolism in healthy middle-aged individuals: results from the Progression of Early Subclinical Atherosclerosis prospective cohort study.The American journal of clinical nutrition · 2026Observational
- Metabolomics and Human Health: Progress, Insights, Challenges and the Concept of a Healthy Metabolome.Biomolecules · 2026Review
- HFrontiers in cell and developmental biology · 2026Review
- The association between high fructose corn syrup and the development of type-2 diabetes.Frontiers in clinical diabetes and healthcare · 2026Review
- Very long-chain saturated fatty acids in plasma lipids: association with cardiometabolic risk influenced by lipid interactions.Cardiovascular diabetology · 2025Article
- Vitamin E and Fatty Acid Intake and Cardiometabolic Multimorbidity Risk: The Mediating Role of Plasma Lipid Metabolites.International journal of molecular sciences · 2025Article
- The physiology of MASLD: molecular pathways between liver and adipose tissues.Clinical science (London, England : 1979) · 2025Review
- Macrophage and inflammation in diabetes and metabolic dysfunction-associated steatotic liver disease: From mechanisms to therapeutic strategies.World journal of diabetes · 2025Review
- Article
- Long-term fasting induces a remodelling of fatty acid composition in erythrocyte membranes.European journal of clinical investigation · 2025Article
- Metabolic complications of psychotropic medications in psychiatric disorders: Emerging role ofWorld journal of psychiatry · 2024Review
- Quantitative Determination of De Novo Fatty Acid Synthesis in Brown Adipose Tissue Using Deuterium Oxide.Journal of visualized experiments : JoVE · 2023Article
- Fructose drives de novo lipogenesis affecting metabolic health.The Journal of endocrinology · 2023Review
- Plasma Lipidomic n-6 Polyunsaturated Fatty Acids and Type 2 Diabetes Risk in the EPIC-Potsdam Prospective Cohort Study.Diabetes care · 2023Article
- Metabolic profiling of MRI-measured liver fat in the UK Biobank.Obesity (Silver Spring, Md.) · 2023Article
- The role of NMR-based circulating metabolic biomarkers in development and risk prediction of new onset type 2 diabetes.Scientific reports · 2022Article
- Visualization and quantification ofAnnals of translational medicine · 2022Article
- Lipogenesis inhibitors: therapeutic opportunities and challenges.Nature reviews. Drug discovery · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
53 authors at 20 institutions in 10 countries.
Fumiaki ImamuraMRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-6841-8396
Amanda M FrettsCardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America.
Matti MarklundDepartment of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-3320-796X
Andres V Ardisson KoratDepartment of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.ORCID 0000-0003-4599-2245
Wei-Sin YangInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei City, the Republic of China.
Maria LankinenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0002-9158-283X
Waqas QureshiSection of Cardiovascular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America.ORCID 0000-0002-5189-4417
Catherine HelmerINSERM, UMR 1219, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France.
Tzu-An ChenUSDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America.
Jyrki K VirtanenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Kerry WongCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia.ORCID 0000-0002-4400-2257
Julie K BassettCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia.ORCID 0000-0003-0799-4821
Rachel MurphyCentre of Excellence in Cancer Prevention, School of Population & Public Health, Faculty of Medicine, The University of British Columbia, Vancouver, Canada.
Nathan TintleDepartment of Mathematics and Statistics, Dordt University, Sioux Center, Iowa, United States of America.ORCID 0000-0003-1447-9107
Chaoyu Ian YuDepartment of Biostatistics, University of Washington School of Public Health, Seattle, Washington, United States of America.
Ingeborg A BrouwerDepartment of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands.ORCID 0000-0002-8762-382X
Kuo-Liong ChienInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei City, the Republic of China.ORCID 0000-0003-4979-8351
Yun-Yu ChenInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei City, the Republic of China.ORCID 0000-0001-7009-7838
Alexis C WoodUSDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America.ORCID 0000-0001-7616-2119
Liana C Del GobboDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, United States of America.
Luc DjousseDivisions of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
Johanna M GeleijnseDivision of Human Nutrition and Health, Wageningen University, Wageningen, the Netherlands.ORCID 0000-0001-7638-0589
Graham G GilesCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia.ORCID 0000-0003-4946-9099
Janette de GoedeDivision of Human Nutrition and Health, Wageningen University, Wageningen, the Netherlands.ORCID 0000-0002-6174-0681
Vilmundur GudnasonIcelandic Heart Association Research Institute, Kopavogur, Iceland.ORCID 0000-0001-5696-0084
William S HarrisDepartment of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, South Dakota, United States of America.ORCID 0000-0003-3042-9353
Allison HodgeCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia.ORCID 0000-0001-5464-2197
Frank HuDepartment of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
InterAct Consortium
Albert KoulmanMRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0001-9998-051X
Markku LaaksoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
Lars LindDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Hung-Ju LinDepartment of Internal Medicine, National Taiwan University Hospital, Taipei City, the Republic of China.
Barbara McKnightDepartment of Biostatistics, University of Washington School of Public Health, Seattle, Washington, United States of America.ORCID 0000-0002-3180-666X
Kalina RajaobelinaINSERM, UMR 1219, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France.
Ulf RiserusDepartment of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-8620-4586
Jennifer G RobinsonPreventive Intervention Center, Departments of Epidemiology, the University of Iowa College of Public Health, Iowa City, Iowa, United States of America.
Cecilia SamieriINSERM, UMR 1219, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France.ORCID 0000-0001-9809-7506
Mackenzie SennUSDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America.ORCID 0000-0002-0298-8142
David S SiscovickThe New York Academy of Medicine, New York, New York, United States of America.ORCID 0000-0003-0461-175X
Sabita S Soedamah-MuthuDivision of Human Nutrition and Health, Wageningen University, Wageningen, the Netherlands.ORCID 0000-0002-8830-3502
Nona SotoodehniaCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America.
Qi SunDepartment of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.ORCID 0000-0002-8480-1563
Michael Y TsaiDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, United States of America.
Tomi-Pekka TuomainenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0002-1949-3787
Matti UusitupaInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Lynne E WagenknechtPublic Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Nick J WarehamMRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0003-1422-2993
Jason H Y WuThe George Institute for Global Health, the Faculty of Medicine, University of New South Wales, Sydney, Australia.ORCID 0000-0003-2073-3562
Renata MichaFriedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, United States of America.ORCID 0000-0002-3983-1632
Rozenn N LemaitreCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America.
Dariush MozaffarianFriedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, United States of America.ORCID 0000-0001-7958-9492
Nita G ForouhiMRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-5041-248X
University of Eastern Finland · FIUniversity of Washington · USBrigham and Women's Hospital · USChildren's Nutrition Research Center at Baylor College of Medicine · USNational Taiwan University · TWTufts University · USUniversité de Bordeaux · FRUniversity of Cambridge · GBCancer Council Victoria · AUThe University of Melbourne · AUUppsala University · SEWageningen University & Research · NLWake Forest University · USDordt University · USIcelandic Heart Association · ISMRC Human Nutrition Research · GBNational Taiwan University Hospital · TWNew York Academy of Medicine · USStanford University · USTilburg University · NL
Funding
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MTransgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI CORKEY, BARBARA E. · 1992 to 2021
$25.0MTraining Program in Cancer EpidemiologyT32CA009001 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI A. Heather Eliassen, Meir Stampfer · 1985 to 2026
$17.3MDietary Etiology of Heart DiseaseR01HL035464 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ERIC B RIMM, Qi Sun · 1986 to 2026
$13.6MCancer Epidemiology Cohort in Male Health ProfessionalsUM1CA167552 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2012 to 2016
$11.5MExceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5MTRAINING GRANT IN ACADEMIC NUTRITIONT32DK007703 · NIDDK · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI CHRISTOPHER P DUGGAN, Frank B Hu · 1994 to 2026
$7.8MCHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6MFatty Acids and Major Cardiovascular OutcomesR01HL085710 · NHLBI · TUFTS UNIVERSITY BOSTON · PI MOZAFFARIAN, DARIUSH · 2006 to 2016
$5.1MCHS Events Follow-up StudyU01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2005 to 2008
$4.6MAlpha Omega TrialR01HL076200 · NHLBI · WAGENINGEN UNIVERSITY · PI KROMHOUT, DAAN · 2005 to 2008
$1.9MDepartment of Health IS-BRC-1215-20014Medical Research Council MC_UU_00006/3Medical Research Council MC_UU_00014/5Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12015/5NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCI NIH HHS T32 CA009001NCI NIH HHS UM1 CA167552NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N01HC55222NHLBI NIH HHS N01HC85079NHLBI NIH HHS N01HC85080NHLBI NIH HHS N01HC85081NHLBI NIH HHS N01HC85082NHLBI NIH HHS N01HC85083NHLBI NIH HHS N01HC85086NHLBI NIH HHS R01 HL035464NHLBI NIH HHS R01 HL076200NHLBI NIH HHS R01 HL085710NHLBI NIH HHS U01 HL047892NHLBI NIH HHS U01 HL047902NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NIA NIH HHS N01 AG012100NIA NIH HHS R01 AG023629NIDDK NIH HHS P30 DK046200NIDDK NIH HHS T32 DK007703
Abstract
backgroundDe novo lipogenesis (DNL) is the primary metabolic pathway synthesizing fatty acids from carbohydrates, protein, or alcohol. Our aim was to examine associations of in vivo levels of selected fatty acids (16:0, 16:1n7, 18:0, 18:1n9) in DNL with incidence of type 2 diabetes (T2D). METHODS AND
findingsSeventeen cohorts from 12 countries (7 from Europe, 7 from the United States, 1 from Australia, 1 from Taiwan; baseline years = 1970-1973 to 2006-2010) conducted harmonized individual-level analyses of associations of DNL-related fatty acids with incident T2D. In total, we evaluated 65,225 participants (mean ages = 52.3-75.5 years; % women = 20.4%-62.3% in 12 cohorts recruiting both sexes) and 15,383 incident cases of T2D over the 9-year follow-up on average. Cohort-specific association of each of 16:0, 16:1n7, 18:0, and 18:1n9 with incident T2D was estimated, adjusted for demographic factors, socioeconomic characteristics, alcohol, smoking, physical activity, dyslipidemia, hypertension, menopausal status, and adiposity. Cohort-specific associations were meta-analyzed with an inverse-variance-weighted approach. Each of the 4 fatty acids positively related to incident T2D. Relative risks (RRs) per cohort-specific range between midpoints of the top and bottom quintiles of fatty acid concentrations were 1.53 (1.41-1.66; p < 0.001) for 16:0, 1.40 (1.33-1.48; p < 0.001) for 16:1n-7, 1.14 (1.05-1.22; p = 0.001) for 18:0, and 1.16 (1.07-1.25; p < 0.001) for 18:1n9. Heterogeneity was seen across cohorts (I2 = 51.1%-73.1% for each fatty acid) but not explained by lipid fractions and global geographical regions. Further adjusted for triglycerides (and 16:0 when appropriate) to evaluate associations independent of overall DNL, the associations remained significant for 16:0, 16:1n7, and 18:0 but were attenuated for 18:1n9 (RR = 1.03, 95% confidence interval (CI) = 0.94-1.13). These findings had limitations in potential reverse causation and residual confounding by imprecisely measured or unmeasured factors.
conclusionsConcentrations of fatty acids in the DNL were positively associated with T2D incidence. Our findings support further work to investigate a possible role of DNL and individual fatty acids in the development of T2D.
Indexed as
LipogenesisAgedDiabetes Mellitus, Type 2Fatty AcidsFemaleHumansIncidenceMaleMetabolic Networks and PathwaysMiddle AgedProspective StudiesFatty Acids
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.