Evidence map›Paper›PMID 32530583›Full record

ArticleThe New England journal of medicine2020

Neuropathological Features of Covid-19.

Isaac H Solomon, Erica Normandin, Shamik Bhattacharyya, Shibani S Mukerji, Kiana Keller, Ahya S Ali, Gordon Adams, Jason L Hornick, Robert F Padera, Pardis Sabeti

Registry-linked trialAbstract readLetter
In one paragraph

Article in The New England journal of medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04775784 (Determination of SARS-Cov-2 Virus in Central Nervous System), which is not on this map. Cited by 531 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
531citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04775784 unknown statusnot on this map

Determination of SARS-Cov-2 Virus in Central Nervous System

TypeobservationalSponsorIRCCS San RaffaeleRan2020 to 2023Enrolled300ConditionsCOVID-19 Testing, CNS Disease, CNS InfectionArmsDetermination of SARS-CoV2 presence in CNS
3 · Its place in the literature

Who cites it

531 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Pooled it
  5. COVID-19 associated cognitive impairment: A systematic review.Cortex; a journal devoted to the study of the nervous system and behavior · 2022
    Pooled it
  6. Molecular Imaging Findings on Acute and Long-Term Effects of COVID-19 on the Brain: A Systematic Review.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Pooled it
  7. Trial
  8. Human brain matters: Navigating the neuropathology of COVID-19.Brain pathology (Zurich, Switzerland) · 2026
    Review
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471 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Isaac H SolomonBrigham and Women's Hospital, Boston, MA ihsolomon@bwh.harvard.edu.ORCID 0000-0003-3432-0902
Erica NormandinBroad Institute, Cambridge, MA.
Shamik BhattacharyyaBrigham and Women's Hospital, Boston, MA.
Shibani S MukerjiMassachusetts General Hospital, Boston, MA.
Kiana KellerMassachusetts General Hospital, Boston, MA.
Ahya S AliBrigham and Women's Hospital, Boston, MA.
Gordon AdamsBroad Institute, Cambridge, MA.
Jason L HornickBrigham and Women's Hospital, Boston, MA.
Robert F PaderaBrigham and Women's Hospital, Boston, MA.
Pardis SabetiBroad Institute, Cambridge, MA.

Funding

Viral Genomics: evolution, spread, and host interactionsU19AI110818 · NIAID · BROAD INSTITUTE, INC. · PI NEAFSEY, DANIEL E · 2014 to 2024
$66.5M
Immune Activation, Cerebral Metabolic Activity and Depression in Treated HIV-InfectionK23MH115812 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI MUKERJI, SHIBANI SHARON · 2018 to 2022
$926k
Howard Hughes Medical InstituteNIAID NIH HHS U19 AI110818NIMH NIH HHS K23 MH115812
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgedAutopsyBetacoronavirusBrainCoronavirus InfectionsCOVID-19FemaleHumansMaleMiddle AgedPandemicsPneumonia, ViralSARS-CoV-2

Identifiers

PMID32530583
PMCPMC7304421

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.