Evidence map›Paper›PMID 32530284›Full record

ArticleJournal of chemical information and modeling2020

Decoding SARS-CoV-2 Transmission and Evolution and Ramifications for COVID-19 Diagnosis, Vaccine, and Medicine.

Rui Wang, Yuta Hozumi, Changchuan Yin, Guo-Wei Wei

Open access · bronzeAbstract read
In one paragraph

Article in Journal of chemical information and modeling, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 1 synthesis or guideline pooled it, 118 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Point mutations at specific sites of the nsp12-nsp8 interface dramatically affect the RNA polymerization activity of SARS-CoV-2.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. The Mutational Landscape of SARS-CoV-2.International journal of molecular sciences · 2023
    Article
  12. Article
  13. Article
  14. SARS-CoV-2 E protein: Pathogenesis and potential therapeutic development.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Rui WangDepartment of Mathematics, Michigan State University, East Lansing, Michigan 48824, United States.
Yuta HozumiDepartment of Mathematics, Michigan State University, East Lansing, Michigan 48824, United States.
Changchuan YinDepartment of Mathematics, Statistics, and Computer Science, University of Illinois at Chicago, Chicago, Illinois 60607, United States.
Guo-Wei WeiDepartment of Mathematics, Michigan State University, East Lansing, Michigan 48824, United States.ORCID 0000-0002-5781-2937
Michigan State University · USUniversity of Illinois Chicago · US

Funding

Synergistic integration of topology and machine learning for the predictions of protein-ligand binding affinities and mutation impactsR01GM126189 · NIGMS · MICHIGAN STATE UNIVERSITY · PI WEI, GUOWEI · 2018 to 2021
$1.4M
NIGMS NIH HHS R01 GM126189
6 · The paper itself

Abstract

Tremendous effort has been given to the development of diagnostic tests, preventive vaccines, and therapeutic medicines for coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Much of this development has been based on the reference genome collected on January 5, 2020. Based on the genotyping of 15 140 genome samples collected up to June 1, 2020, we report that SARS-CoV-2 has undergone 8309 single mutations which can be clustered into six subtypes. We introduce mutation ratio and mutation

Indexed as

COVID-19Antibodies, ViralCoronavirus 3C ProteasesCoronavirus Envelope ProteinsCoronavirus Nucleocapsid ProteinsCoronavirus Papain-Like ProteasesEndoribonucleasesGenome, ViralGenotypeGeographyHumansMutant ProteinsMutationPhosphoproteinsProtein ConformationSARS-CoV-2Antibodies, ViralCoronavirus 3C ProteasesCoronavirus Envelope ProteinsCoronavirus Nucleocapsid ProteinsCoronavirus Papain-Like ProteasesEndoribonucleasesenvelope protein, SARS-CoV-2Mutant Proteinsnidoviral uridylate-specific endoribonucleasenucleocapsid phosphoprotein, SARS-CoV-2PhosphoproteinsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2VaccinesViral Nonstructural Proteins

Identifiers

PMID32530284
PMCPMC7318555
OpenAlexW3034738177

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.