ArticleHead & neck2020
False-positive reverse transcriptase polymerase chain reaction screening for SARS-CoV-2 in the setting of urgent head and neck surgery and otolaryngologic emergencies during the pandemic: Clinical implications.
Article in Head & neck, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Artificial Intelligence/Machine Learning-Based Diagnostic Software as a Medical Device Using Forced Cough Vocalization Signal Data Signatures in the Diagnosis of COVID-19 Illness
Evaluation of the Artificial Intelligence/Machine Learning-Based Diagnostic Software as a Medical Device Using Forced Cough Vocalization Signal Data Signatures in the Diagnosis of COVID-19 Illness: A Prospective, Two-Arm Non-Inferiority Clinical Validation Trial of AudibleHealth Dx Software as a Medical Device (EUA-US)
Who cites it
27 citing papers in PubMed.
- Optimizing surveillance: feasibility of pooled sample testing for bovine alphaherpesvirus 1 detection by real-time PCR.Virusdisease · 2025Article
- ADDRESSING SELECTION BIAS AND MEASUREMENT ERROR IN COVID-19 CASE COUNT DATA USING AUXILIARY INFORMATION.The annals of applied statistics · 2023Article
- Comparison of the performance of two real-time fluorescent quantitative PCR kits for the detection of SARS-CoV-2 nucleic acid: a study based on large real clinical samples.Virology journal · 2022Article
- A Review of SARS-CoV-2 Disease (COVID-19): Pandemic in Our Time.Pathogens (Basel, Switzerland) · 2022Review
- Wastewater, waste, and water-based epidemiology (WWW-BE): A novel hypothesis and decision-support tool to unravel COVID-19 in low-income settings?The Science of the total environment · 2022Review
- Evaluation of a comprehensive pre-procedural screening protocol for COVID-19 in times of a high SARS CoV-2 prevalence: a prospective cross-sectional study.Annals of medicine · 2021Article
- The Impact of False Positive COVID-19 Result.Cureus · 2021Article
- The utility of SARS-CoV-2-specific serology in COVID-19 diagnosis.Australian and New Zealand journal of public health · 2021Article
- Evaluation of spike protein antigens for SARS-CoV-2 serology.Journal of virological methods · 2021Article
- Mass spectrometry analytical responses to the SARS-CoV2 coronavirus in review.Trends in analytical chemistry : TRAC · 2021Review
- Simultaneous detection and mutation surveillance of SARS-CoV-2 and multiple respiratory viruses by rapid field-deployable sequencing.Med (New York, N.Y.) · 2021Article
- Combination of rRT-PCR and Anti-Nucleocapsid/Anti-Spike Antibodies to Characterize Specimens with Very Low Viral SARs-CoV-2 Load: A Real-Life Experience.Microorganisms · 2021Article
- Natural unblinding of BCG vaccination trials.Vaccine · 2021Article
- Article
- Radiological and clinical spectrum of COVID-19: A major concern for public health.World journal of radiology · 2021Review
- Modeling the effect of exposure notification and non-pharmaceutical interventions on COVID-19 transmission in Washington state.NPJ digital medicine · 2021Article
- False Positive Results With SARS-CoV-2 RT-PCR Tests and How to Evaluate a RT-PCR-Positive Test for the Possibility of a False Positive Result.Journal of occupational and environmental medicine · 2021Article
- A case of SARS-CoV-2 reinfection in a patient with obstructive sleep apnea managed with telemedicine.BMJ case reports · 2021Article
- Diagnostic Efficiency of Three Fully Automated Serology Assays and Their Correlation with a Novel Surrogate Virus Neutralization Test in Symptomatic and Asymptomatic SARS-COV-2 Individuals.Microorganisms · 2021Article
- Physicians' Dilemma of False-Positive RT-PCR for COVID-19: a Case Report.SN comprehensive clinical medicine · 2021Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNo reports describe falsepositive reverse transcriptase polymerase chain reaction (RT-PCR) for novel coronavirus in preoperative screening.
methodsPreoperative patients had one or two nasopharyngeal swabs, depending on low or high risk of viral transmission. Positive tests were repeated.
resultsForty-three of 52 patients required two or more preoperative tests. Four (9.3%) had discrepant results (positive/negative). One of these left the coronavirus disease (COVID) unit against medical advice despite an orbital abscess, with unknown true disease status. The remaining 3 of 42 (7.1%) had negative repeat RT-PCR. Although ultimately considered falsepositives, one was sent to a COVID unit postoperatively and two had urgent surgery delayed. Assuming negative repeat RT-PCR, clear chest imaging, and lack of subsequent symptoms represent the "gold standard," RT-PCR specificity was 0.97.
conclusionsIf false positives are suspected, we recommend computed tomography (CT) of the chest and repeat RT-PCR. Validated serum immunoglobulin testing may ultimately prove useful.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.