Evidence map›Paper›PMID 32530059›Full record

ArticleJournal of neuroscience research2020

Caudate nuclei volume alterations and cognition and mood dysfunctions in adolescents with single ventricle heart disease.

Sarah Noorani, Bhaswati Roy, Ashish K Sahib, Cristina Cabrera-Mino, Nancy J Halnon, Mary A Woo, Alan B Lewis, Nancy A Pike, Rajesh Kumar

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroscience research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06326996 (Thiamine Intervention and Cognition in Older Adults Undergoing Coronary Artery Bypass Grafting - A Randomized Clinical Trial.), which is not on this map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06326996 early_phase1recruitingnot on this mapstarted 2024, after this paper: background citation

Thiamine Intervention and Cognition in Older Adults Undergoing Coronary Artery Bypass Grafting - A Randomized Clinical Trial.

TypeinterventionalSponsorUniversity of California, Los AngelesRan2024 to 2026Enrolled52ConditionsCoronary Heart Disease, Coronary Artery Bypass GraftingArmsThiamine, Placebo
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Sarah NooraniDepartment of Anesthesiology, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-3289-4120
Bhaswati RoyDepartment of Anesthesiology, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA, USA.
Ashish K SahibDepartment of Anesthesiology, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA, USA.
Cristina Cabrera-MinoUCLA School of Nursing, University of California Los Angeles, Los Angeles, CA, USA.
Nancy J HalnonDivision of Pediatric Cardiology, University of California Los Angeles, Los Angeles, CA, USA.
Mary A WooUCLA School of Nursing, University of California Los Angeles, Los Angeles, CA, USA.
Alan B LewisDivision of Pediatric Cardiology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Nancy A PikeUCLA School of Nursing, University of California Los Angeles, Los Angeles, CA, USA.
Rajesh KumarDepartment of Anesthesiology, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-5355-9586
University of California, Los Angeles · USChildren's Hospital of Los Angeles · US

Funding

Cerebral Artery Integrity Linked to Brain Injury and Cognition in Congenital Heart DiseaseR01NR016463 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUMAR, RAJESH, PIKE, NANCY ANN · 2016 to 2019
$2.0M
NINR NIH HHS R01 NR-016463NINR NIH HHS R01 NR016463
6 · The paper itself

Abstract

Adolescents with single ventricle heart disease (SVHD) exhibit mood and cognitive deficits, which may result from injury to the basal ganglia structures, including the caudate nuclei. However, the integrity of the caudate in SVHD adolescents is unclear. Our aim was to examine the global and regional caudate volumes, and evaluate the relationships between caudate volumes and cognitive and mood scores in SVHD and healthy adolescents. We acquired two high-resolution T1-weighted images from 23 SVHD and 37 controls using a 3.0-Tesla MRI scanner, as well as assessed mood (Patient Health Questionnaire-9 [PHQ-9]; Beck Anxiety Inventory [BAI]) and cognition (Montreal Cognitive Assessment [MoCA]; Wide Range Assessment of Memory and Learning-2; General Memory Index [GMI]) functions. Both left and right caudate nuclei were outlined, which were then used to calculate and compare volumes between groups using ANCOVA (covariates: age, gender, and head-size), as well as perform 3D surface morphometry. Partial correlations (covariates: age, gender, and head-size) were used to examine associations between caudate volumes, cognition, and mood scores in SVHD and controls. SVHD subjects showed significantly higher PHQ-9 and BAI scores, indicating more depressive and anxiety symptoms, as well as reduced GMI scores, suggesting impaired cognition, compared to controls. SVHD patients showed significantly reduced caudate volumes (left, 3,198.8 ± 490.1 vs. 3,605.0 ± 480.4 mm

Indexed as

Adolescent BehaviorAdolescentCaudate NucleusCognitive DysfunctionFemaleHumansMaleMental Status and Dementia TestsMood DisordersOrgan SizeVentricular Dysfunction3D surface morphometryanxietybasal gangliacongenital heart diseasedepressionmagnetic resonance imaging

Identifiers

PMID32530059
PMCPMC8925167
OpenAlexW3034668644

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.