Evidence map›Paper›PMID 32529922›Full record

ArticleUnited European gastroenterology journal2020

Wound healing of metastatic perineal Crohn's disease using hyperbaric oxygen therapy: A case series.

Corine A Lansdorp, Christianne J Buskens, Krisztina B Gecse, Geert Ram D'Haens, Rob A Van Hulst

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in United European gastroenterology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  13. Emerging treatment strategies in wound care.International wound journal · 2022
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  17. A Review of Hyperbaric Oxygen Therapy for Inflammatory Bowel Disease.International journal of general medicine · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Corine A LansdorpDepartment of Anaesthesiology/Hyperbaric Medicine, Amsterdam University Medical Centre, Location AMC, Amsterdam, The Netherlands.ORCID 0000-0001-9395-4003
Christianne J BuskensDepartment of Surgery, Amsterdam University Medical Centre, Location AMC, Amsterdam, The Netherlands.
Krisztina B GecseDepartment of Gastroenterology and Hepatology, Amsterdam University Medical Centre, Location AMC, Amsterdam, The Netherlands.
Geert Ram D'HaensDepartment of Gastroenterology and Hepatology, Amsterdam University Medical Centre, Location AMC, Amsterdam, The Netherlands.
Rob A Van HulstDepartment of Anaesthesiology/Hyperbaric Medicine, Amsterdam University Medical Centre, Location AMC, Amsterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMetastatic Crohn's disease (CD) is a rare manifestation of CD. It involves inflammatory skin lesions with histopathological findings (granulomas) similar to CD, without connection to the gastrointestinal tract. Hyperbaric oxygen therapy (HBO) has been suggested as a possible treatment option.

objectiveThis study aimed to identify and treat a consecutive series of patients with biopsy-proven metastatic CD and monitor wound healing using prospectively acquired outcomes.

methodsPathology results of all patients with ongoing perineal wound-healing problems after proctectomy between 2005 and 2018 at the Amsterdam University Medical Centre were assessed for metastatic CD. Patients with a biopsy-proven diagnosis of perineal metastatic CD were offered HBO (40 daily sessions of 100% oxygen at 2.4 atmosphere absolute). Wound healing was monitored using photographs and standardised questionnaires (the Inflammatory Bowel Disease Questionnaire, EuroQol Visual Analogue Scale and the Female Sexual Function Index) at baseline and 1 and 3 months after HBO.

resultsOut of 13 patients in the cohort with persisting perineal wounds after proctectomy, six (46%) had biopsy results consistent with metastatic CD. Of these, three accepted treatment with HBO. All three patients were female. One patient had complete healing of her perineal wound; another patient showed initial improvement but had a flare of luminal and perineal disease at the 3-month follow-up. The third patient showed improvement solely in the questionnaires, with higher scores on all three questionnaires.

conclusionA high rate of metastatic CD was found in patients with ongoing wound-healing problems after proctectomy, implying that the disease might not be as rare in these selected patients as previously thought. HBO might be beneficial in the treatment of metastatic CD.

Indexed as

Wound HealingAdultBiopsyCrohn DiseaseFemaleFollow-Up StudiesGranulomaHumansHyperbaric OxygenationMiddle AgedPerineumPhotographyPostoperative ComplicationsProctectomyProspective StudiesRectal Fistulacutaneous manifestationsInflammatory bowel diseasewound healing

Identifiers

PMID32529922
PMCPMC7435003

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.