Evidence map›Paper›PMID 32529906›Full record

Trial reportEmerging microbes & infections2020

Serological differentiation between COVID-19 and SARS infections.

Wan Ni Chia, Chee Wah Tan, Randy Foo, Adrian Eng Zheng Kang, Yilong Peng, Velraj Sivalingam, Charles Tiu, Xin Mei Ong, Feng Zhu, Barnaby E Young and 5 more

Open access · goldAbstract readClinical TrialComparative Study
In one paragraph

Trial report in Emerging microbes & infections, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 105 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Observational
  5. Article
  6. Review
  7. Long term SARS-CoV-2-specific cellular immunity after COVID-19 in liver transplant recipients.Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. [Change in serum IgG antibody during the recovery stage of Omicron variant infection in children: an analysis of 110 cases].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022
    Article
  12. Current vaccine strategies against SARS-CoV-2: Promises and challenges.The Journal of allergy and clinical immunology · 2022
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Long-Term Persistence of Spike Protein Antibody and Predictive Modeling of Antibody Dynamics After Infection With Severe Acute Respiratory Syndrome Coronavirus 2.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Observational
  18. Receptor-binding domain-based immunoassays for serosurveillance differentiate efficiently between SARS-CoV2-exposed and non-exposed farmed mink.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Wan Ni ChiaProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.ORCID https://orcid.org/0000-0001-7287-694X
Chee Wah TanProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.ORCID https://orcid.org/0000-0001-9837-1413
Randy FooProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
Adrian Eng Zheng KangProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
Yilong PengProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
Velraj SivalingamProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
Charles TiuProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
Xin Mei OngProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
Feng ZhuProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.ORCID https://orcid.org/0000-0002-8131-1219
Barnaby E YoungNational Centre for Infectious Diseases, Singapore, Singapore.
Mark I-C ChenNational Centre for Infectious Diseases, Singapore, Singapore.ORCID https://orcid.org/0000-0001-9369-5830
Yee-Joo TanDepartment of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore, Singapore, Singapore.
David C LyeNational Centre for Infectious Diseases, Singapore, Singapore.
Danielle E AndersonProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.ORCID https://orcid.org/0000-0003-4791-5024
Lin-Fa WangProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.ORCID https://orcid.org/0000-0003-2752-0535
Duke-NUS Medical School · SGNational University of Singapore · SGAgency for Science, Technology and Research · SGNanyang Technological University · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In response to the coronavirus disease 2019 (COVID-19) outbreak, caused by SARS-CoV-2, multiple diagnostic tests are required for acute disease diagnosis, contact tracing, monitoring asymptomatic infection rates and assessing herd immunity. While PCR remains the frontline test of choice in the acute diagnostic setting, serological tests are urgently needed. Unlike PCR tests which are highly specific, cross-reactivity is a major challenge for COVID-19 antibody tests considering there are six other coronaviruses known to infect humans. SARS-CoV is genetically related to SARS-CoV-2 sharing approximately 80% sequence identity and both belong to the species

Indexed as

Antibodies, ViralBetacoronavirusClinical Laboratory TechniquesCoronavirus InfectionsCoronavirus Nucleocapsid ProteinsCOVID-19COVID-19 TestingCross ReactionsDiagnosis, DifferentialEnzyme-Linked Immunosorbent AssayHEK293 CellsHumansImmunoprecipitationNucleocapsid ProteinsPandemicsPhosphoproteinsAntibodies, ViralCoronavirus Nucleocapsid Proteinsnucleocapsid phosphoprotein, SARS-CoV-2Nucleocapsid ProteinsPhosphoproteinsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2antibodyCOVID-19SARSSARS-CoV-2serology

Identifiers

PMID32529906
PMCPMC7473126
OpenAlexW3034844298

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.