ArticleThe Journal of international medical research2020
Leptin improves intestinal flora dysfunction in mice with high-fat diet-induced obesity.
Article in The Journal of international medical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Combined acupuncture and herb treatment improves intestinal flora inabdominally obese subjects based on 16s rRNA sequencing: a randomized controlled trial.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026Trial
- Ananalysis of the effects of Treg cell therapy intervention on the gut microbiota of type 1 diabetic mice using 16S rRNA gene sequencing.Experimental biology and medicine (Maywood, N.J.) · 2026Article
- Article
- Leptin's crucial modulatory role in regulating body mass homeostasis of high-fat-fed striped field mice (Frontiers in physiology · 2025Article
- Influence of Bariatric Surgery on Gut Microbiota Composition and Its Implication on Brain and Peripheral Targets.Nutrients · 2024Review
- Effects of lactoferrin on intestinal flora of metabolic disorder mice.BMC microbiology · 2022Article
- An Extract ofAnimals : an open access journal from MDPI · 2022Article
- Analysis of gut microbiome composition, function, and phenotype in patients with osteoarthritis.Frontiers in microbiology · 2022Article
- Dysbiosis of Gut Microbiota in Patients With Acute Myocardial Infarction.Frontiers in microbiology · 2021Article
- Electroacupuncture Combined With Diet Treatment Has a Therapeutic Effect on Perimenopausal Patients With Abdominal Obesity by Improving the Community Structure of Intestinal Flora.Frontiers in physiology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study investigated the effects of leptin on intestinal flora and inflammation in mice with high-fat diet (HFD)-induced obesity.
methodsMice were fed an HFD for 8 weeks; some were concurrently administered oral leptin for 4 weeks. Pathological changes in adipose tissue were detected using hematoxylin-eosin staining; endotoxin content in adipose tissue was measured by enzyme-linked immunosorbent assay. Intestinal flora were characterized by 16S bacterial rDNA sequencing. Levels of Toll-like receptor 4 (TLR4), nuclear factor-κB inhibitor α (IκB-α), and phosphorylated c-Jun N-terminal kinase (p-JNK) were detected by western blotting.
resultsMice in the HFD group exhibited weight gain, elevated endotoxin content, and adipocyte hypertrophy, compared with the non-obese control group. Moreover, abundance of bacteria in the
conclusionLeptin administration improved intestinal flora dysfunction and inflammation in mice with HFD-induced obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.