Evidence map›Paper›PMID 32529807›Full record

ArticlePharmacology research & perspectives2020

Agonist bias and agonist-dependent antagonism at corticotrophin releasing factor receptors.

Zoe Tasma, Peter Wills, Debbie L Hay, Christopher S Walker

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacology research & perspectives, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Zoe TasmaSchool of Biological Sciences, University of Auckland, Auckland, New Zealand.ORCID 0000-0002-7652-6004
Peter WillsSchool of Biological Sciences, University of Auckland, Auckland, New Zealand.
Debbie L HaySchool of Biological Sciences, University of Auckland, Auckland, New Zealand.ORCID 0000-0002-9558-5122
Christopher S WalkerSchool of Biological Sciences, University of Auckland, Auckland, New Zealand.ORCID 0000-0001-8151-4123
University of Auckland · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The corticotropin-releasing factor (CRF) receptors represent potential drug targets for the treatment of anxiety, stress, and other disorders. However, it is not known if endogenous CRF receptor agonists display biased signaling, how effective CRF receptor antagonists are at blocking different agonists and signaling pathways or how receptor activity-modifying proteins (RAMPs) effect these processes. This study aimed to address this by investigating agonist and antagonist action at CRF

Indexed as

AnimalsChlorocebus aethiopsCorticotropin-Releasing HormoneCOS CellsCRF Receptor, Type 1Cyclic AMPDrug DevelopmentHEK293 CellsHumansInositol PhosphatesReceptor Activity-Modifying Protein 1Receptor Activity-Modifying Protein 2Receptors, Corticotropin-Releasing HormoneSignal TransductionUrocortinsCorticotropin-Releasing HormoneCRF Receptor, Type 1CRF receptor type 2Cyclic AMPInositol PhosphatesRAMP1 protein, humanRAMP2 protein, humanReceptor Activity-Modifying Protein 1Receptor Activity-Modifying Protein 2Receptors, Corticotropin-Releasing HormoneUrocortinscorticotropin releasing factorCRF1CRF2functional selectivityintracellular signalingprobe-dependent antagonism

Identifiers

PMID32529807
PMCPMC7290078
OpenAlexW3034756976

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.