Evidence map›Paper›PMID 32529583›Full record

ArticleInternational journal of hematology2020

A case of human herpesvirus 6 encephalitis following pediatric hematopoietic stem cell transplantation: early diagnosis and treatment matters.

Atsushi Sakamoto, Masaki Yamada, Shin-Ichi Tsujimoto, Tomoo Osumi, Katsuhiro Arai, Daisuke Tomizawa, Akira Ishiguro, Kimikazu Matsumoto, Ken-Ichi Imadome, Motohiro Kato

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In one paragraph

Article in International journal of hematology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Atsushi SakamotoCenter for Postgraduate Education and Training, National Center for Child Health and Development, Tokyo, Japan.ORCID http://orcid.org/0000-0002-2222-5425
Masaki YamadaDepartment of Advanced Medicine for Viral Infections, Tokyo, Japan. yamada-mas@ncchd.go.jp.
Shin-Ichi TsujimotoChildren's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
Tomoo OsumiChildren's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
Katsuhiro AraiDivision of Gastroenterology, National Center for Child Health and Development, Tokyo, Japan.
Daisuke TomizawaChildren's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
Akira IshiguroCenter for Postgraduate Education and Training, National Center for Child Health and Development, Tokyo, Japan.
Kimikazu MatsumotoChildren's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
Ken-Ichi ImadomeDepartment of Advanced Medicine for Viral Infections, Tokyo, Japan.
Motohiro KatoChildren's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
National Center For Child Health and Development · JPTokyo Yamate Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human herpesvirus 6 (HHV-6) is one of the life-threatening infectious complications with significant morbidity and mortality following hematopoietic stem cell transplantation (HSCT). Clinically, the diagnosis of HHV-6 encephalitis can be challenging due to a lack of specific symptoms and definitive diagnostic tests. We report a pediatric HSCT recipient who developed late-onset HHV-6 encephalitis without typical radiographic findings. The routine viral infection monitoring protocol contributed to the prompt diagnosis of HHV-6 encephalitis and early therapeutic intervention. The patient was treated successfully without any neurological complications attributable to HHV-6 encephalitis. HHV-6 encephalitis should remain in the differential diagnosis as an important but treatable disease, even for several months after HSCT and even without radiographic findings. Whenever HHV-6 encephalitis is suspected, antivirals should be initiated promptly to prevent its complications.

Indexed as

Early DiagnosisHerpesvirus 6, HumanAntiviral AgentsChildChild, PreschoolDiagnosis, DifferentialDiagnostic Tests, RoutineEncephalitis, ViralHematopoietic Stem Cell TransplantationHumansMalePostoperative ComplicationsRoseolovirus InfectionsTransplantation, HomologousAntiviral AgentsHematopoietic stem cell transplantationHuman herpesvirus 6Post-transplant encephalitisViral load

Identifiers

PMID32529583
OpenAlexW3035543996

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.