Evidence map›Paper›PMID 32529578›Full record

ArticleJournal of neurology2020

Modern machine-learning can support diagnostic differentiation of central and peripheral acute vestibular disorders.

Seyed-Ahmad Ahmadi, Gerome Vivar, Nassir Navab, Ken Möhwald, Andreas Maier, Hristo Hadzhikolev, Thomas Brandt, Eva Grill, Marianne Dieterich, Klaus Jahn and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. A digital neurotology history: Characteristics and inter-rater reliability.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
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  9. Bibliometric analysis of global research trends in vestibular neuritis (1980-2024).European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
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  11. Neurological update: neuro-otology 2023.Journal of neurology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Seyed-Ahmad AhmadiGerman Center for Vertigo and Balance Disorders, Ludwig-Maximilians-University, Munich, Germany.
Gerome VivarGerman Center for Vertigo and Balance Disorders, Ludwig-Maximilians-University, Munich, Germany.
Nassir NavabComputer Aided Medical Procedures, Technical University, Munich, Germany.
Ken MöhwaldGerman Center for Vertigo and Balance Disorders, Ludwig-Maximilians-University, Munich, Germany.
Andreas MaierGerman Center for Vertigo and Balance Disorders, Ludwig-Maximilians-University, Munich, Germany.
Hristo HadzhikolevGerman Center for Vertigo and Balance Disorders, Ludwig-Maximilians-University, Munich, Germany.
Thomas BrandtGerman Center for Vertigo and Balance Disorders, Ludwig-Maximilians-University, Munich, Germany.
Eva GrillGerman Center for Vertigo and Balance Disorders, Ludwig-Maximilians-University, Munich, Germany.
Marianne DieterichGerman Center for Vertigo and Balance Disorders, Ludwig-Maximilians-University, Munich, Germany.
Klaus JahnGerman Center for Vertigo and Balance Disorders, Ludwig-Maximilians-University, Munich, Germany.
Andreas ZwergalGerman Center for Vertigo and Balance Disorders, Ludwig-Maximilians-University, Munich, Germany. andreas.zwergal@med.uni-muenchen.de.ORCID http://orcid.org/0000-0002-3839-8398
German Center for Lung Research · DEMunich Cluster for Systems Neurology · DETechnical University of Munich · DEZimmer Biomet (Netherlands) · NL

Funding

Bundesministerium für Bildung und Forschung 01EO0901
6 · The paper itself

Abstract

backgroundDiagnostic classification of central vs. peripheral etiologies in acute vestibular disorders remains a challenge in the emergency setting. Novel machine-learning methods may help to support diagnostic decisions. In the current study, we tested the performance of standard and machine-learning approaches in the classification of consecutive patients with acute central or peripheral vestibular disorders.

methods40 Patients with vestibular stroke (19 with and 21 without acute vestibular syndrome (AVS), defined by the presence of spontaneous nystagmus) and 68 patients with peripheral AVS due to vestibular neuritis were recruited in the emergency department, in the context of the prospective EMVERT trial (EMergency VERTigo). All patients received a standardized neuro-otological examination including videooculography and posturography in the acute symptomatic stage and an MRI within 7 days after symptom onset. Diagnostic performance of state-of-the-art scores, such as HINTS (Head Impulse, gaze-evoked Nystagmus, Test of Skew) and ABCD

resultsMachine-learning methods (e.g., MultiGMC) outperform univariate scores, such as HINTS or ABCD

conclusionsEstablished clinical scores (such as HINTS) provide a valuable baseline assessment for stroke detection in acute vestibular syndromes. In addition, machine-learning methods may have the potential to increase sensitivity and selectivity in the establishment of a correct diagnosis.

Indexed as

Nystagmus, PathologicVestibular NeuronitisHumansMachine LearningProspective StudiesVertigoAcute vestibular syndromeHINTSMachine-learningMRIVestibular neuritisVestibular stroke

Identifiers

PMID32529578
PMCPMC7718180
OpenAlexW3035420347

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.