ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2022
Observer repeatability and interscan reproducibility of 18F-sodium fluoride coronary microcalcification activity.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Pooled it
- Effects of Evolocumab on Coronary Plaque Composition and Microcalcification Activity by Coronary PET and CT Angiography.JACC. Cardiovascular imaging · 2025Trial
- Head-to-head comparison ofJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2024Trial
- Microcalcification: Effects on Atherosclerotic Vulnerable Plaques, Detection, and Therapeutic Perspectives.Current atherosclerosis reports · 2026Review
- From incidental positron emission uptake toFrontiers in cardiovascular medicine · 2026Review
- Emerging Applications of Positron Emission Tomography in Coronary Artery Disease.Journal of personalized medicine · 2025Review
- Beyond the Lumen: Molecular Imaging to Unmask Vulnerable Coronary Plaques.Journal of cardiovascular development and disease · 2025Review
- Qualitative and quantitative analysis of 18F-GP1 positron emission tomography in thrombotic cardiovascular disease.Scientific reports · 2024Article
- Sex differences in coronary atherosclerotic plaque activity usingEuropean journal of nuclear medicine and molecular imaging · 2024Article
- Coronary Atherosclerotic Plaque Activity and Risk of Myocardial Infarction.Journal of the American College of Cardiology · 2024Article
- The clinical value of quantitative cardiovascular molecular imaging: a step towards precision medicine.The British journal of radiology · 2023Review
- Temporal Changes in CoronaryJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- Latent Coronary Plaque Morphology From Computed Tomography Angiography, Molecular Disease Activity on Positron Emission Tomography, and Clinical Outcomes.Arteriosclerosis, thrombosis, and vascular biology · 2023Article
- The Role of Positron Emission Tomography in Advancing the Understanding of the Pathogenesis of Heart and Vascular Diseases.Diagnostics (Basel, Switzerland) · 2023Review
- Advanced Cardiac Imaging in the Assessment of Aortic Stenosis.Journal of cardiovascular development and disease · 2023Review
- Advances in the Assessment of Coronary Artery Disease Activity with PET/CT and CTA.Tomography (Ann Arbor, Mich.) · 2023Review
- Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Thoracic AorticJACC. Cardiovascular imaging · 2022Observational
- Bypass Grafting and Native Coronary Artery Disease Activity.JACC. Cardiovascular imaging · 2022Article
- Respiration-averaged CT versus standard CT attenuation map for correction ofJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
Corrections and comments
- Commented on by
Authors and funding
14 authors at 4 institutions in 4 countries.
Funding
Abstract
backgroundWe aimed to establish the observer repeatability and interscan reproducibility of coronary
methodsPatients with multivessel coronary artery disease underwent repeated hybrid PET and computed tomography angiography (CTA) imaging (PET/CTA). CMA was defined as the integrated standardized uptake values (SUV) in the entire coronary tree exceeding 2 standard deviations above the background SUV. Coefficients of repeatability between the same observer (intraobserver repeatability), between 2 observers (interobserver repeatability) and coefficient of reproducibility between 2 scans (interscan reproducibility), were determined at vessel and patient level.
resultsIn 19 patients, CMA was assessed twice in 43 coronary vessels on two PET/CT scans performed 12 ± 5 days apart. There was excellent intraclass correlation for intraobserver and interobserver repeatability as well as interscan reproducibility (all ≥ 0.991). There was 100% intraobserver, interobserver and interscan agreement for the presence (CMA > 0) or absence (CMA = 0) of coronary
conclusionsCMA is a repeatable and reproducible global measure of coronary atherosclerotic activity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.