Evidence map›Paper›PMID 32529520›Full record

ArticleSleep & breathing = Schlaf & Atmung2021

Smoking and sleep apnea duration mediated the sex difference in daytime sleepiness in OSA patients.

Xingjian Wang, Wenyang Li, Jiawei Zhou, Zhijing Wei, Xiaomeng Li, Jiahuan Xu, Fang Zhang, Wei Wang

Abstract read
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In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xingjian WangInstitute of Respiratory and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Wenyang LiInstitute of Respiratory and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Jiawei ZhouInstitute of Respiratory and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Zhijing WeiInstitute of Respiratory and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Xiaomeng LiInstitute of Respiratory and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Jiahuan XuDepartment of Respiratory Medicine, Zhejiang Hospital, Hangzhou, Zhejiang, China.
Fang ZhangInstitute of Respiratory and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Wei WangInstitute of Respiratory and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, Liaoning, China. wwbycmu@126.com.ORCID http://orcid.org/0000-0003-3454-966X
First Hospital of China Medical University · CNZhejiang Hospital · CN

Funding

the Construction Project of Translational Medicine Research Center of Respiratory Disease of Liaoning Province of China 2014225006the National Key Research and Development Program of China 2018YFC1313600the National Natural Science Foundation of China 81670085
6 · The paper itself

Abstract

purposeDaytime sleepiness is a common symptom of obstructive sleep apnea (OSA) and is more common in men, but the underlying mechanism remains unclear. The aim of this study was to assess whether or not sex differences in daytime sleepiness persisted after controlling for age and OSA severity and to explore the factors contributing to daytime sleepiness in patients with OSA.

methodsA total of 104 pairs of patients with OSA, matched by age and apnea-hypopnea index (AHI), were enrolled in this retrospective study. Demographic data were collected; daytime sleepiness was measured by the Epworth Sleepiness Scale (ESS); and polysomnography (PSG) was performed on each participant. These measurements were compared between sexes, and the factors affecting daytime sleepiness were explored with correlation and multivariate linear regression analyses.

resultsMen had significantly higher ESS scores (p = 0.021) than women. Regarding demographics, BMI, neck/height ratio, and proportion of habitual smoking and alcohol intake were significantly higher in men. Regarding PSG findings, men had more rapid eye movement sleep, a longer mean apnea-hypopnea duration, and a longer mean apnea duration (MAD). Regression analysis showed that two sex-associated variables, habitual smoking (β = 0.189, p = 0.006) and MAD (β = 0.154, p = 0.024), had the strongest association with ESS scores. Further analysis revealed that MAD was significantly influenced by apnea index (β = 0.306, p < 0.001) and sex (β = - 0.193, p = 0.003).

conclusionThe sex difference in daytime sleepiness persists in patients with OSA, even after matching AHI and age. The difference is mediated by sex-specific smoking habits and sex differences in apnea duration.

Indexed as

AdultCigarette SmokingDisorders of Excessive SomnolenceFemaleHumansMaleMiddle AgedRetrospective StudiesSeverity of Illness IndexSex CharacteristicsSex FactorsSleep Apnea, ObstructiveSleep, REMTime FactorsDaytime sleepinessMean apnea durationObstructive sleep apneaSex

Identifiers

PMID32529520
OpenAlexW3197520729

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.