Evidence map›Paper›PMID 32529491›Full record

ArticleBehavior genetics2020

The (Broad-Sense) Genetic Correlations Among Four Measures of Inattention and Hyperactivity in 12 Year Olds.

Conor V Dolan, Eveline L de Zeeuw, Tetyana Zayats, C E M van Beijsterveldt, Dorret I Boomsma

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavior genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Conor V DolanDepartment of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Van der Boechorststraat 7-9, 1081 BT, Amsterdam, The Netherlands. c.v.dolan@vu.nl.
Eveline L de ZeeuwDepartment of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Van der Boechorststraat 7-9, 1081 BT, Amsterdam, The Netherlands.
Tetyana ZayatsAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
C E M van BeijsterveldtDepartment of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Van der Boechorststraat 7-9, 1081 BT, Amsterdam, The Netherlands.
Dorret I BoomsmaDepartment of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Van der Boechorststraat 7-9, 1081 BT, Amsterdam, The Netherlands. di.boomsma@vu.nl.
Vrije Universiteit Amsterdam · NLBroad Institute · USPublic Health Service of Amsterdam · NL

Funding

2/7 Psychiatric Genomics Consortium: Finding Actionable VariationU01MH109539 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI DALY, MARK JOSEPH · 2016 to 2020
$4.7M
EPA EP-C-15-001FP7 Ideas: European Research Council 602768Koninklijke Nederlandse Akademie van Wetenschappen PAH/6635Nederlandse Organisatie voor Wetenschappelijk Onderzoek 0240-001-003Nederlandse Organisatie voor Wetenschappelijk Onderzoek 056-32-010Nederlandse Organisatie voor Wetenschappelijk Onderzoek 406-12-124Nederlandse Organisatie voor Wetenschappelijk Onderzoek 480-15-001/674Nederlandse Organisatie voor Wetenschappelijk Onderzoek 481-08-011NIMH NIH HHS U01 MH109539
6 · The paper itself

Abstract

We estimated the genetic covariance matrix among four inattention (INATT) and four hyperactivity (HYP) measures in the classical twin design. Data on INATT and HYP symptom counts were obtained in mono- and dizygotic twin pairs (N = 1593) with an average age of 12.2 years (sd = .51). We analyzed maternal ratings of INATT and HYP based on the Conners' Parent Rating Scale (CPRS), the Strengths and Weaknesses of ADHD-symptoms and Normal-behavior (SWAN), and teacher ratings based on the Conners' Teacher rating scale (CTRS) and the ASEBA Teacher Rating Form (TRF). Broad-sense heritabilities, corrected for the main effects of sex and for random teacher rater effects, were large (ranging from .658 to .912). The results reveal pervasive and strong broad-sense genetic effects on INATT and HYP phenotypes with the phenotypic covariance among the phenotypes largely due to correlated genetic effects. Specifically between 79.9 and 99.9% of the phenotypic covariance among the HYP measures, and between 81.0 and 93.5% of the INATT measures are attributable to broad-sense genetic effects. Overall, the present results, pertaining to the broad-sense heritabilities and shared genetic effects, support the current genome-wide association meta-analytic approach to identifying pleiotropic genetic variants.

Indexed as

AttentionAttention Deficit Disorder with HyperactivityChildCognitionDiseases in TwinsFamilyFemaleGenome-Wide Association StudyGenotypeHumansMaleParentsPhenotypeTwins, DizygoticTwins, MonozygoticADHDGenetic correlationHyperactivityInattentionMultivariate genetic modelTwin design

Identifiers

PMID32529491
PMCPMC7355270
OpenAlexW3034803037

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.