Evidence map›Paper›PMID 32529476›Full record

SynthesisInflammation research : official journal of the European Histamine Research Society ... [et al.]2020

The association between IL18, FOXP3 and IL13 genes polymorphisms and risk of allergic rhinitis: a meta-analysis.

Liang Tang, Yongjun Chen, Qin Xiang, Ju Xiang, Yonghong Tang, Jianming Li

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Role of Th2, Th17 and Treg Cells and relevant cytokines in pathogenesis of allergic rhinitis.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2024
    Article
  16. Article
  17. The Assessment ofJournal of asthma and allergy · 2023
    Article
  18. Article
  19. Journal of asthma and allergy · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Liang Tang *Department of Anatomy, Changsha Medical University, Changsha, 410219, China.
Yongjun Chen *Department of Neurology, Nanhua Affiliated Hospital, University of South China, Hengyang, 421001, China.
Qin XiangDepartment of Anatomy, Changsha Medical University, Changsha, 410219, China.
Ju XiangDepartment of Anatomy, Changsha Medical University, Changsha, 410219, China.
Yonghong TangDepartment of Neurology, Nanhua Affiliated Hospital, University of South China, Hengyang, 421001, China. tyh6246@163.com.
Jianming LiDepartment of Anatomy, Changsha Medical University, Changsha, 410219, China. ljming0901@sina.com.ORCID http://orcid.org/0000-0002-5012-0989

Funding

National Natural Science Foundation of China 81873780
6 · The paper itself

Abstract

objectivesAllergic rhinitis (AR) is a chronic inflammatory disease of nasal mucosa. Loss of function of Th17 cells and regulatory T (Treg) cells plays a role in the pathogenesis of AR. IL18, FOXP3, and IL13 are key genes in the development of AR. However, the genetic associations between IL18, FOXP3 and IL13 genes polymorphisms and AR risk were inconclusive yet.

methodsA meta-analysis was performed by searching through Pubmed, EMBASE, web of science and CNKI databases. The ORs and 95%CIs were used to assess the genetic association between the allelic, dominant and recessive models of IL18, FOXP3 and IL13 genes polymorphisms and AR risk.

resultsA total of 15 articles (6 for FOXP3, 5 for IL18, and 5 for IL13) were enrolled in the present study. No association was detected between the IL18 rs187238, rs1946518, rs360721, FOXP3 rs2232365, rs3761548 and IL13 rs1800925 polymorphisms and AR risk (p > 0.05). Significant associations were observed between the allelic (p = 0.001, OR 1.32, 95% CI 1.12-1.56), dominant (p = 0.005, OR 1.43, 95% CI 1.11-1.83) and recessive models (p = 0.01, OR 1.64, 95% CI 1.13, 2.40) of IL13 rs20541 and AR risk. Subgroup analysis based on ethnicity revealed that the IL13 rs20541 was significantly associated with AR risk in Asian population (allelic model: p = 0.009, OR 1.36, 95% CI 1.13-1.63, dominant model: p = 0.005, OR 1.43, 95% CI 1.11-1.83; recessive model: p = 0.01, OR 1.64, 95% CI 1.13-2.40).

conclusionsIL13 rs20541 may contribute to the risk of AR in Asian population. To confirm these results, larger number of case-control study with more subjects is necessary in the future.

Indexed as

Genetic Predisposition to DiseasePolymorphism, GeneticAsian PeopleForkhead Transcription FactorsHumansInterleukin-13Interleukin-18Publication BiasRhinitis, AllergicRiskForkhead Transcription FactorsFOXP3 protein, humanInterleukin-13Interleukin-18Allergic rhinitisFOXP3IL13IL18Meta-analysisPolymorphism

Identifiers

PMID32529476

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.