Evidence map›Paper›PMID 32529465›Full record

ArticleHuman cell2020

MiR-645 regulates the proliferation and apoptosis of diffuse large B-cell lymphoma by targeting DACH1.

Ruihuan Wang, Jie Shen, Na Su, Qing Wang, Minjuan Zhang, Chunyan Liu

Abstract read
PubMed Publisher
In one paragraph

Article in Human cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ruihuan WangThe Second Hematology Department, Cangzhou Central Hospital, No. 16 Xinhua West Street, Cangzhou, 061001, Hebei, China. doc_first@aliyun.com.ORCID http://orcid.org/0000-0003-0235-952X
Jie ShenThe Second Hematology Department, Cangzhou Central Hospital, No. 16 Xinhua West Street, Cangzhou, 061001, Hebei, China.
Na SuThe CDC of Xinhua District, Cangzhou, 061000, Hebei, China.
Qing WangThe Second Hematology Department, Cangzhou Central Hospital, No. 16 Xinhua West Street, Cangzhou, 061001, Hebei, China.
Minjuan ZhangThe Second Hematology Department, Cangzhou Central Hospital, No. 16 Xinhua West Street, Cangzhou, 061001, Hebei, China.
Chunyan LiuThe Second Hematology Department, Cangzhou Central Hospital, No. 16 Xinhua West Street, Cangzhou, 061001, Hebei, China.
Cangzhou Central Hospital · CN

Funding

Cangzhou Science and Technology Support Technology Project 141302108
6 · The paper itself

Abstract

Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of malignant non-Hodgkin lymphoma cases. An increasing body of evidence has indicated the critical roles of microRNAs (miRNAs) in regulating the progression of DLBCL. In this study, we found that miR-645 was up-regulated in DLBCL tissues and cell lines. Down-regulation of miR-645 significantly inhibited the proliferation, cell cycle progression and promoted the apoptosis of DLBCL cells. Experimental study identified Dachshund family transcription factor 1 (DACH1) as a target of miR-645. MiR-645 bound the 3'-untranslated region of DACH1 and reduced the expression of DACH1 in DLBCL cells. Decreased expression of DACH1 was inversely correlated with that of miR-645 in DLBCL tissues. The promoting effect of miR-645 on the proliferation of DLBCL cells was attenuated with the overexpression of DACH1. These results demonstrated the novel mechanism of miR-645 in DLBCL, which indicated miR-645 as a potential target for the diagnosis and prognostics of DLBCL.

Indexed as

Gene ExpressionApoptosisCell Line, TumorCell ProliferationEye ProteinsGene Expression Regulation, NeoplasticHumansLymphoma, Large B-Cell, DiffuseMicroRNAsMolecular Targeted TherapyPrognosisTranscription FactorsDACH1 protein, humanEye ProteinsMicroRNAsMIRN645 microRNA, humanTranscription FactorsDACH1DLBCLmiR-645

Identifiers

PMID32529465
OpenAlexW3035023958

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.