Evidence map›Paper›PMID 32529460›Full record

ArticleImmunologic research2020

Soluble CD83 suppresses experimental food allergy via regulating aberrant T helper 2 responses.

Wenyue Song, Hongfen Li, Bingkun Jia, Zhenxi Wang, Qingsheng Liu, Guangping Yang, Xiaorong Li

Abstract read
PubMed Publisher
In one paragraph

Article in Immunologic research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. New insights into the mechanisms of childhood food allergies.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Wenyue SongDepartments of Pediatrics, Obstetrics and Gynecology, Jiaozuo Women and Children Hospital, 158 Minzhu Zhong Road, Jiaozuo, 454150, China.
Hongfen LiDepartments of Pediatrics, Obstetrics and Gynecology, Jiaozuo Women and Children Hospital, 158 Minzhu Zhong Road, Jiaozuo, 454150, China.
Bingkun JiaDepartments of Pediatrics, Obstetrics and Gynecology, Jiaozuo Women and Children Hospital, 158 Minzhu Zhong Road, Jiaozuo, 454150, China.
Zhenxi WangDepartments of Pediatrics, Obstetrics and Gynecology, Jiaozuo Women and Children Hospital, 158 Minzhu Zhong Road, Jiaozuo, 454150, China.
Qingsheng LiuDepartments of Pediatrics, Obstetrics and Gynecology, Jiaozuo Women and Children Hospital, 158 Minzhu Zhong Road, Jiaozuo, 454150, China.
Guangping YangDepartments of Pediatrics, Obstetrics and Gynecology, Jiaozuo Women and Children Hospital, 158 Minzhu Zhong Road, Jiaozuo, 454150, China.
Xiaorong LiDepartments of Pediatrics, Obstetrics and Gynecology, Jiaozuo Women and Children Hospital, 158 Minzhu Zhong Road, Jiaozuo, 454150, China. boryang@sina.com.ORCID 0000-0002-5390-8560
Jiaozuo University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aberrant T helper-2 (Th2) responses play a critical role in the pathogenesis of allergic diseases. The underlying mechanism is to be further investigated. It is reported that soluble CD83 (sCD83) has immune-regulatory effects. This study aims to investigate the role of sCD83 in the regulation of Th2 polarization. Blood samples were collected from pediatric patients with food allergy (FA). The Th2 response was analyzed by pertinent immunological approaches. An FA murine model was developed to test the role of sCD83 in the regulation of FA response. We found that the serum sCD83 levels were lower in FA patients. A negative correlation was detected between serum sCD83 levels and serum Th2 cytokine levels. The presence of sCD83 suppressed Th2 cell differentiation and antigen-specific Th2 cell activation. sCD83 upregulated the T-bet expression and suppressed the GATA3 expression in CD4

Indexed as

AdolescentAnimalsAntigens, CDCD83 AntigenCells, CulturedChildDisease Models, AnimalEgg HypersensitivityFemaleGATA3 Transcription FactorGene Expression RegulationHumansImmunoglobulinsLymphocyte ActivationMaleMembrane GlycoproteinsAntigens, CDCD83 AntigenGATA3 protein, humanGata3 protein, mouseGATA3 Transcription FactorImmunoglobulinsMembrane GlycoproteinsOvalbuminT-bet Transcription FactorT-Box Domain ProteinsFood allergyImmune regulationIntestineSoluble CD83Th2 response

Identifiers

PMID32529460
OpenAlexW3034566511

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.