ArticleJournal of neuro-oncology2020
Management of incidental anterior skull base large and giant meningiomas in elderly patients.
Article in Journal of neuro-oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Clinical predictors of overall survival in very elderly meningioma patients: a surveillance, epidemiology, and end results (SEER) database analysis.Journal of neuro-oncology · 2025Article
- Optimal treatment regimen for very elderly patients with atypical meningioma: an analysis of survival outcomes using the National Cancer Database (NCDB).Journal of neuro-oncology · 2025Article
- Giant skull base meningiomas: Definitions, case reports, and surgical approaches.Surgical neurology international · 2025Article
- Article
- A nomogram for predicting the risk of major postoperative complications for patients with meningioma.Neurosurgical review · 2023Article
- Meningioma in the elderly.Neuro-oncology advances · 2023Article
- Older meningioma patients: a retrospective population-based study of risk factors for morbidity and mortality after neurosurgery.Acta neurochirurgica · 2022Article
- Perioperative Complication Profile of Skull Base Meningioma Resection in Older versus Younger Adult Patients.Journal of neurological surgery. Part B, Skull base · 2022Article
- The Surgical Risk Factors of Giant Intracranial Meningiomas: A Multi-Centric Retrospective Analysis of Large Case Serie.Brain sciences · 2022Article
- Risks and neurological benefits of meningioma surgery in elderly patients compared to young patients.Journal of neuro-oncology · 2021Article
- Surgery on giant meningiomas in very old patients entails frequent postoperative intracranial hemorrhages and atypical histopathology.Journal of neuro-oncology · 2021Article
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Authors and funding
9 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionThe incidence of meningiomas among the elderly is considered to be high, and are at increased risk of severe morbidity and mortality following surgery due to their aging physiology and unexpected comorbidities. This study aimed to evaluate the optimal management strategies of meningiomas in elderly patients.
methodsWe retrospectively analyzed 150 patients with incidental large (≥ 3 cm) and giant (≥ 6 cm) anterior skull base meningiomas from 2009 to 2018. These patients were divided into elderly group (≥ 65 years, n = 70) and younger group (< 65 years, n = 80). Information of patients with regard to their medical records, operative details, relevant imaging, and follow-up data were obtained from their respective electronic medical records.
resultsThe elderly patients had significantly longer length of hospital stay (15.9 ± 3.5) compared to younger patients (13.6 ± 3.6, P < 0.001). Karnofsky Performance Scale (KPS) at discharge was significantly lower in elderly group when compared to younger group (P = 0.04). However, the KPS at 1-year after surgery was similar between the two groups. In addition, there was no significant difference in the incidence of surgical complications between the two groups. Multivariate regression analysis of postoperative complications revealed blood loss ≥ 800 mL (P = 0.007) and BMI (< 18.5 or ≥ 24, P < 0.001) as risk factors, rather than age.
conclusionsSurgical resection in elderly patients with incidental anterior skull base large and giant meningiomas is considered to be a safe and effective therapeutic option owing to acceptable mortality, postoperative complications and postoperative clinical outcomes.
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