Observational studyJournal of gastrointestinal cancer2021
The Correlation Between Helicobacter pylori Infection and Lnc-OC1 Expression in Gastric Cancer Tissues in an Iranian Population.
Observational study in Journal of gastrointestinal cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- PVT1 and ZFAS1 lncRNAs expressions and their biomarker value in gastric cancer tissue sampling among Iranian population.Molecular biology reports · 2021Trial
- Article
- CircRNA_15430 reduced by Helicobacter pylori infection and suppressed gastric cancer progression via miR-382-5p/ZCCHC14 axis.Biology direct · 2023Article
- Prognostic Value of LncRNA KRT18P55 in Patients with Intestinal Type of Gastric Cancer.Journal of gastrointestinal cancer · 2022Article
- Overexpression of HOXA-AS2 LncRNA in Patients with Gastric Cancer and Its Association with Helicobacter pylori Infection.Journal of gastrointestinal cancer · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe role of Lnc_OC1 in gastric cancer (GC) has not been well documented. The very purpose of the present study was to determine not only the expression of Lnc_OC1 in gastric tissues but also its role in the formation of GC. Furthermore, the expression levels of Lnc-OC1 were examined in H. pylori-positive versus H. pylori-negative GC tissues.
methodsTumor and adjacent normal tissues were collected from 43 patients with GC. RNA extraction and cDNA synthesis were performed. Then, qRT-PCR was carried out. Finally, an independent sample t test was run to examine the expression level of Lnc_OC1 in a GC and normal tissues using SPSS program.
resultsThe results revealed a significantly higher expression level of Lnc_OC1 in the GC tissues as compared with the normal tissues (p = 0.0037). The correlations between the expression level of Lnc_OC1 and the clinical features of patients were not statistically significant (p > 0.05). Moreover, the expression of Lnc-OC1 was significantly higher in H. pylori-positive patients as compared with H. pylori-negative patients (p = 0.01).
conclusionThe findings of the present study revealed that deregulation of Lnc_OC1 may have a role in the H. pylori-associated pathogenesis of GC. Moreover, a direct association can be speculated between GC formation and Lnc_OC1 expression. The mentioned findings highlight the potential role of Lnc_OC1 as a prognostic biomarker of GC. Hence, further evaluations are required in this respect.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.