Evidence map›Paper›PMID 32529356›Full record

SynthesisNeuropsychology review2020

The Effects of Cognitive Training on Brain Network Activity and Connectivity in Aging and Neurodegenerative Diseases: a Systematic Review.

Tim D van Balkom, Odile A van den Heuvel, Henk W Berendse, Ysbrand D van der Werf, Chris Vriend

Open access · hybridAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neuropsychology review, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 8 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 8 syntheses or guidelines pooled it, 110 citations in OpenAlex.

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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Tim D van BalkomAmsterdam UMC, Psychiatry, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, De Boelelaan, 1117, Amsterdam, Netherlands. t.vanbalkom@amsterdamumc.nl.ORCID 0000-0002-6643-2776
Odile A van den HeuvelAmsterdam UMC, Psychiatry, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, De Boelelaan, 1117, Amsterdam, Netherlands.ORCID 0000-0002-9804-7653
Henk W BerendseAmsterdam UMC, Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, De Boelelaan, 1117, Amsterdam, Netherlands.
Ysbrand D van der WerfAmsterdam UMC, Anatomy and Neurosciences, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, De Boelelaan, 1117, Amsterdam, Netherlands.
Chris VriendAmsterdam UMC, Psychiatry, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, De Boelelaan, 1117, Amsterdam, Netherlands.ORCID 0000-0003-3111-1304
Amsterdam Neuroscience · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognitive training (CT) is an increasingly popular, non-pharmacological intervention for improving cognitive functioning in neurodegenerative diseases and healthy aging. Although meta-analyses support the efficacy of CT in improving cognitive functioning, the neural mechanisms underlying the effects of CT are still unclear. We performed a systematic review of literature in the PubMed, Embase and PsycINFO databases on controlled CT trials (N > 20) in aging and neurodegenerative diseases with pre- and post-training functional MRI outcomes up to November 23rd 2018 (PROSPERO registration number CRD42019103662). Twenty articles were eligible for our systematic review. We distinguished between multi-domain and single-domain CT. CT induced both increases and decreases in task-related functional activation, possibly indicative of an inverted U-shaped curve association between regional brain activity and task performance. Functional connectivity within 'cognitive' brain networks was consistently reported to increase after CT while a minority of studies additionally reported increased segregation of frontoparietal and default mode brain networks. Although we acknowledge the large heterogeneity in type of CT, imaging methodology, in-scanner task paradigm and analysis methods between studies, we propose a working model of the effects of CT on brain activity and connectivity in the context of current knowledge on compensatory mechanisms that are associated with aging and neurodegenerative diseases.

Indexed as

Neural PathwaysAdolescentAdultAgedAged, 80 and overAgingBrainBrain MappingCognitionCognition DisordersFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeurodegenerative DiseasesAgingCognitive trainingMagnetic resonance imagingNetworkNeurodegenerative diseasesNeuroimaging

Identifiers

PMID32529356
PMCPMC7305076
OpenAlexW3034890258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.