Evidence map›Paper›PMID 32529351›Full record

ArticleVirchows Archiv : an international journal of pathology2021

Genetic variant of SRF-rearranged myofibroma with a misleading nuclear expression of STAT6 and STAT6 involvement as 3' fusion partner.

Hugo Nihous, Nicolas Macagno, Jessica Baud-Massière, Aurélie Haffner, Jean-Luc Jouve, Jean-Claude Gentet, Camille Touzery, François Le Loarer, Corinne Bouvier

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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Hugo NihousDepartment of Pathology, INSERM, MMG, APHM, CHU Timone, Aix Marseille University, Marseille, France.ORCID http://orcid.org/0000-0001-7981-1903
Nicolas MacagnoDepartment of Pathology, INSERM, MMG, APHM, CHU Timone, Aix Marseille University, Marseille, France.ORCID https://orcid.org/0000-0002-9882-2162
Jessica Baud-MassièreDepartment of Pathology, Institut Bergonié, Bordeaux, France.
Aurélie HaffnerDepartment of Pathology, INSERM, MMG, APHM, CHU Timone, Aix Marseille University, Marseille, France.
Jean-Luc JouveDepartment of Pediatric orthopedic, APHM, La Timone Children's Hospital, Marseille, France.
Jean-Claude GentetDepartment of Pediatric Hematology and Oncology, APHM, La Timone Children's Hospital, Marseille, France.
Camille TouzeryDepartment of Radiology, APHM, Hopital Nord, Marseille, France.
François Le LoarerDepartment of Pathology, Institut Bergonié, Bordeaux, France.
Corinne BouvierDepartment of Pathology, INSERM, MMG, APHM, CHU Timone, Aix Marseille University, Marseille, France. corinne.Bouvier2@ap-hm.fr.
Inserm · FRHôpital de la Timone · FRInstitut Bergonié · FRHôpital Nord · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pediatric neoplasms with a myofibroblastic differentiation are frequent in children, in particular myofibroma. Recently, a novel deep soft tissue myofibroblastic neoplasm has been described with high cellularity, a smooth muscle phenotype and SRF-RELA fusion. We report the case of a 15-year-old boy who presented with a tumor of the deep soft tissue of the arm, with overlapping histological features with the recently described SRF-RELA group of myofibromas but differing by the presence of calcifications, a novel SRF-STAT6 fusion transcript and nuclear expression of STAT6. No local recurrence nor distant metastasis was detected at the current follow-up of 29 months. The clinical relevance of this novel fusion requires further investigations.

Indexed as

Gene FusionGene RearrangementAdolescentBiomarkers, TumorCell NucleusHumansImmunohistochemistryMaleMyofibromaSequence Analysis, RNASerum Response FactorSoft Tissue NeoplasmsSTAT6 Transcription FactorUpper ExtremityBiomarkers, TumorSerum Response FactorSRF protein, humanSTAT6 protein, humanSTAT6 Transcription FactorLeiomyomaMyofibroblastic proliferationMyofibromaMyopericytomaPediatricRELASmooth muscle neoplasmSRFSTAT6

Identifiers

PMID32529351
OpenAlexW3034840752

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.