ArticlePediatric nephrology (Berlin, Germany)2020
Prevalence of arterial hypertension, hemodynamic phenotypes, and left ventricular hypertrophy in children after coarctation repair: a multicenter cross-sectional study.
Article in Pediatric nephrology (Berlin, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 17 citations in OpenAlex.
- Severity and duration-dependent aortic stiffening in a rabbit coarctation model identifies constitutive material parameters as promising regional biomarkers for hypertension progression.Scientific reports · 2026Article
- Association of Plasma Renin Activity with Risk of Late Hypertension in Pediatric Patients with Early Aortic Coarctation Repair: A Retrospective Study.Life (Basel, Switzerland) · 2025Article
- Computational model of coarctation of the aorta in rabbits suggests persistent ascending aortic remodeling post-correction.Biomechanics and modeling in mechanobiology · 2025Article
- Primary aortic coarctation repair in adolescents and adults.JTCVS structural and endovascular · 2024Article
- Influence of Aortic Arch Morphology on Renal Perfusion in Patients with Coarctation of the Aorta: An Exploratory Study.Medicina (Kaunas, Lithuania) · 2024Article
- Aortic Remodeling Kinetics in Response to Coarctation-Induced Mechanical Perturbations.Biomedicines · 2023Article
- Clinical, Experimental, and Computational Validation of a New Doppler-Based Index for Coarctation Severity Assessment.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2022Article
- Follow-up of hypertension after aortic coarctation stent implantation based on safe and effective re-intervention: a retrospective cohort study.Journal of thoracic disease · 2022Article
- Hypertension after coarctation repair-a systematic review.Translational pediatrics · 2022Review
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to evaluate hemodynamic phenotypes and prevalence of left ventricular hypertrophy in children after coarctation repair with right arm and leg blood pressure difference < 20 mmHg. Secondary objectives were analysis of effects of age at intervention, residual gradient across the descending aorta, and type of correction.
methodsBlood pressure status and left ventricular hypertrophy were diagnosed according to European Society of Hypertension 2016 guidelines.
resultsOf 90 patients with a median age 12.5 (8.9-15.8) years, 8.5 (6.0-11.8) years after coarctation repair who were included, 42 (46.7%) were hypertensive. Isolated systolic hypertension dominated among 29 hypertensive patients with uncontrolled or masked hypertension (25 of 29; 86.2%). Of the 48 patients with office normotension, 14.6% (7) had masked hypertension, 8.3% (4) had ambulatory prehypertension, and 54.2% (26) were truly normotensive. Left ventricular hypertrophy was diagnosed in 29 patients (32.2%), including 14 of 42 (33.3%) hypertensive and 15 of 48 (31.3%) normotensive patients. The peak systolic gradient across the descending aorta was greater in hypertensive subjects (33.3 ± 12.7 mmHg) compared with normotensive subjects (25 ± 8.2 mmHg, p = 0.0008). Surgical correction was performed earlier than percutaneous intervention (p < 0.0001) and dominated in 40 of 48 (83.3%) normotensive versus 24 of 42 (57.1%) hypertensive patients (p = 0.006).
conclusionsArterial hypertension with isolated systolic hypertension as the dominant phenotype and left ventricular hypertrophy are prevalent even after successful coarctation repair. Coarctation correction from the age of 9 years and older was associated with a higher prevalence of hypertension.
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