SynthesisClinical neuroradiology2020
Deep Cerebral Venous Thrombosis Treatment : Endovascular Case using Aspiration and Review of the Various Treatment Modalities.
Synthesis in Clinical neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Mechanical Thrombectomy for Aseptic, Atraumatic, Medically Refractory Cerebral Venous Sinus Thrombosis: a Systematic Review.Clinical neuroradiology · 2024Pooled it
- Cerebral Venous Thrombosis in Patients with COVID-19 Infection: a Case Series and Systematic Review.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2020Pooled it
- Endovascular treatment of cerebral venous thrombosis involving the deep venous system.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Case Report: Mechanical thrombectomy using stent retriever devices in deep cerebral venous thrombosis: illustrative cases.Frontiers in stroke · 2025Article
- Evolution and advances in endovascular mechanical thrombectomy of cerebral venous sinus thrombosis.International journal of medical sciences · 2024Review
- Deep cerebral venous system involvement in patients with cerebral sinus thrombosis. A proposal of neuroradiological score systems useful for clinical assessment.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Coronavirus disease 19 (COVID-19) and Cerebral venous sinus thrombosis (CVST): A case series and review of the literature.Clinical case reports · 2022Article
- Endovascular Treatment of Intracranial Vein and Venous Sinus Thrombosis-A Systematic Review.Journal of clinical medicine · 2022Review
- Safety and efficacy of endovascular thrombectomy in patients with severe cerebral venous thrombosis: A meta-analysis.Journal of central nervous system disease · 2022Article
- Predictive Factors for Early-Onset Seizures in Patients With Cerebral Venous Sinus Thrombosis.Frontiers in neurology · 2022Article
- Use of Stent Retriever Thrombectomy Combined With Local Urokinase Thrombolysis for Deep Cerebral Vein Thrombosis: A Case Report.Frontiers in stroke · 2022Article
- COVID-19 Associated Coagulopathy Resulting in Cerebral Venous Thrombosis and Pulmonary Embolism.Cureus · 2021Article
- Factors influencing therapy choice and clinical outcome in cerebral venous sinus thrombosis.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDeep cerebral venous thrombosis (CVT) is an uncommon condition with a high morbidity and mortality. The optimal treatment approach for deep CVT remains uncertain and due to its low prevalence, randomized trials are not feasible. We showcase a straight sinus thrombosis treated with a large bore aspiration and performed a meta-analysis of the available literature to characterize and evaluate the various treatment modalities for patients with deep CVT.
methodsWe conducted a systematic search in PubMed, EMBASE and Ovid Medline using appropriate keywords/MESH terms search strategy. All patients with thrombosis involving the deep venous sinuses were included if treatment records were available. Outcome measures included recanalization of the affected sinus, good functional outcome assessed by a modified Rankin scale (mRS) of 0-2 or reported independent functional outcomes, permanent neurological deficits, further hemorrhage and mortality.
resultsA total of 69 studies comprising 120 patients were included in the analysis. Anticoagulation was the most common treatment (85.8%), whilst local intrasinus thrombolysis was performed in 40.0% of the patients and mechanical endovascular modalities were employed in 20.0% of the patients. Recanalization of the occluded sinus was seen in 83.5% of the patients while 62.6% patients achieved good functional outcome. There was considerable morbidity with 60.7% having a permanent neurological deficit, 23.3% having further hemorrhage after admission and 18.6% mortality. In the cohort receiving anticoagulation, 65.3% achieved good outcome but intracranial hemorrhage at presentation was associated with poorer outcome, permanent deficits, further bleeding and mortality.
conclusionAnticoagulation is an effective treatment strategy for deep CVT; however, patients with intracranial hemorrhage at presentation often have poorer outcomes and early endovascular strategies could be considered in this subgroup.
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