Evidence map›Paper›PMID 32529250›Full record

ReviewBiology of reproduction2020

The new contraceptive revolution: developing innovative products outside of industry†,‡.

Rebecca L Callahan, Neha J Mehta, Kavita Nanda, Gregory S Kopf

Abstract readReview
In one paragraph

Review in Biology of reproduction, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. A platform utilizingProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rebecca L CallahanReproductive Health Product Innovation & Introduction, Global Health Population & Nutrition, FHI 360, Durham, NC, USA.
Neha J MehtaReproductive Health Product Innovation & Introduction, Global Health Population & Nutrition, FHI 360, Durham, NC, USA.
Kavita NandaReproductive Health Product Innovation & Introduction, Global Health Population & Nutrition, FHI 360, Durham, NC, USA.
Gregory S KopfReproductive Health Product Innovation & Introduction, Global Health Population & Nutrition, FHI 360, Durham, NC, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A significant global unmet need for new contraceptive options for both women and men remains due to side effect profiles, medical concerns, and inconvenience of many currently available products. The pharmaceutical industry has largely abandoned early research and development for contraception and will not likely engage to bring new products to the market unless they have been significantly de-risked by showing promise in early phase clinical trials. This lack of interest by big pharma comes at a time when scientific and technological advances in biology and medicine are creating more opportunities than ever for the development of new and innovative drug products. Novel partnerships between the academic sector, small biotechnology companies, foundations, non-government organizations (NGOs), and the federal government could accelerate the development of new contraceptive products. We discuss the challenges and opportunities that we have encountered as an NGO with a mission to develop novel contraceptive products for low- and middle-income countries and how it differs from developing products for higher-income markets. We hope that our experiences and "lessons learned" will be of value to others as they proceed down the product development path, be it for female or male or for hormonal or nonhormonal contraceptives.

Indexed as

ContraceptionContraceptive AgentsDrug DevelopmentHumansContraceptive Agentsacceptabilityclinical trialfirst-in-humanmarket researchpharmaceutical developmentpreclinical developmentregulatory strategytarget product profileuser preferences

Identifiers

PMID32529250
PMCPMC7401029

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.