ArticleKidney3602020
Prevalence and Persistence of Uremic Symptoms in Incident Dialysis Patients.
Article in Kidney360, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Initiation of Dialysis Is Associated With Impaired Cardiovascular Functional Capacity.Journal of the American Heart Association · 2022Trial
- Review
- A Metabolomics Approach To Identify Metabolites Associated with Uremic Symptoms in Patients Receiving Maintenance Hemodialysis.Kidney360 · 2026Article
- "You Gotta Keep Climbing That Mountain to Reach the Goal": Perspectives of Transplant Waitlisted Dialysis Patients. A Qualitative Study.Kidney medicine · 2026Article
- The Impact of Hemodiafiltration Versus Hemodialysis on Uremic Symptoms, Physical Function: A Systematic Review and Meta-analysis of Randomized Controlled Trials.Kidney medicine · 2025Article
- Article
- CKD-associated pruritus in haemodialysis: a road map for diagnosis and treatment.Clinical kidney journal · 2025Review
- Better Dialysis Care in the United States Requires New Payment Policy: No Patient Left Behind.Journal of the American Society of Nephrology : JASN · 2025Article
- A Pragmatic Randomized Controlled Trial of a CKD-Specific Virtual Monitoring Platform to Minimize Adverse Outcomes in High-Risk CKD Patients: A Clinical Research Protocol.Canadian journal of kidney health and disease · 2025Article
- A Metabolomics Approach to Identify Metabolites Associated With Mortality in Patients Receiving Maintenance Hemodialysis.Kidney international reports · 2024Article
- Article
- Review
- Stigma and related factors among renal dialysis patients in China.Frontiers in psychiatry · 2023Article
- The relationship between uremic toxins and symptoms in older men and women with advanced chronic kidney disease.Clinical kidney journal · 2022Article
- Patient-centred approaches for the management of unpleasant symptoms in kidney disease.Nature reviews. Nephrology · 2022Review
- A metabolomics approach identified toxins associated with uremic symptoms in advanced chronic kidney disease.Kidney international · 2022Article
- European hemodialysis patient satisfaction with phosphate binders is associated with serum phosphorus levels: the Dialysis Outcomes and Practice Patterns Study.Clinical kidney journal · 2021Article
- The current and future landscape of dialysis.Nature reviews. Nephrology · 2020Review
- Correlation of sleep quality and cardiac autonomic modulation in hemodialysis patients.Sleep science (Sao Paulo, Brazil)Article
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 2 countries.
Funding
Abstract
backgroundUremic symptoms are major contributors to the poor quality of life among patients on dialysis, but whether their prevalence or intensity has changed over time is unknown.
methodsWe examined responses to validated questionnaires in two incident dialysis cohort studies, the Choices for Health Outcomes in Caring for ESRD (CHOICE) study (
resultsIn CHOICE and LUCID, respectively, mean age of the participants was 58 and 60 years, 53% and 60% were male, and 28% and 32% were black. In both cohorts, 54% of the participants had diabetes. Median time from dialysis initiation to the symptoms questionnaires was 45 days for CHOICE and 77 days for LUCID. Uremic symptom prevalence in CHOICE did not change from baseline to 1-year follow-up and was similar across CHOICE and LUCID. Baseline symptom prevalence in CHOICE and LUCID was as follows: anorexia (44%, 44%, respectively), nausea/vomiting (36%, 43%), pruritus (72%, 63%), sleepiness (86%, 68%), difficulty concentrating (55%, 57%), fatigue (89%, 77%), and pain (82%, 79%). In both cohorts, >80% of patients had three or more symptoms and >50% had five or more symptoms. The correlation between individual symptoms was low (
conclusionsThe burden of uremic symptoms among patients on dialysis is substantial and has not changed in the past 15 years. Improving quality of life will require identification of the factors that underlie the pathogenesis of uremic symptoms and better ways of removing the toxins that are responsible.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.