ArticleEClinicalMedicine2020
Low serum DHEA-S is associated with impaired lung function in women.
Article in EClinicalMedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Anabolic-androgenic steroids for patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis.Frontiers in medicine · 2022Pooled it
- Randomized study of the effects of testosterone administration on severity of asthma in horses.Journal of veterinary internal medicine · 2026Article
- Sex, hormones, and lung health.Physiological reviews · 2026Review
- The serum evaluation of sex hormones including DHEAs, DHT, testosterone in oral lichen planus patients.Scientific reports · 2025Article
- Analysis of Endocrine and Inflammatory Markers in Preserved Ratio Impaired Spirometry.Medical sciences (Basel, Switzerland) · 2024Article
- The impact of hormones on lung development and function: an overlooked aspect to consider from early childhood.Frontiers in endocrinology · 2024Review
- Article
- Clinical and Immunological Markers of Pulmonary Impairment Among People With HIV in India.Open forum infectious diseases · 2022Article
- Sex and gender in asthma.European respiratory review : an official journal of the European Respiratory Society · 2021Review
- Sex and gender in respiratory physiology.European respiratory review : an official journal of the European Respiratory Society · 2021Article
- [The role of counterinsular hormones in the regulation of glucose homeostasis and the pathogenesis of type 2 diabetes mellitus in COPD].Problemy endokrinologii · 2021Article
Corrections and comments
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Authors and funding
29 authors at 20 institutions in 12 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEmerging evidence suggests that androgens and estrogens have a role in respiratory health, but it is largely unknown whether levels of these hormones can affect lung function in adults from the general population. This study investigated whether serum dehydroepiandrosterone sulfate (DHEA-S), a key precursor of both androgens and estrogens in peripheral tissues, was related to lung function in adult women participating in the European Community Respiratory Health Survey (ECRHS).
methodsLung function and serum DHEA-S concentrations were measured in
findingsWomen with low DHEA-S (z-score<-1) had lower FEV1 (% of predicted, adjusted difference: -2.2; 95%CI: -3.5 to -0.9) and FVC (-1.7; 95%CI: -2.9 to -0.5) and were at a greater risk of having airflow limitation and restrictive pattern on spirometry than women with higher DHEA-S levels. In longitudinal analyses, low DHEA-S at baseline was associated with a greater incidence of airflow limitation after an 11-years follow-up (incidence rate ratio, 3.43; 95%CI: 1.91 to 6.14).
interpretationLow DHEA-S levels in women were associated with impaired lung function and a greater risk of developing airflow limitation later in adult life. Our findings provide new evidence supporting a role of DHEA-S in respiratory health.
fundingEU H2020, grant agreement no.633212.
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