Evidence map›Paper›PMID 32529027›Full record

ArticleMolecular therapy oncolytics2020

Robert S Bayne, Shelby Puckett, Lindsey Ulkus Rodrigues, Scott D Cramer, Jingyun Lee, Cristina M Furdui, Jeff W Chou, Lance D Miller, David A Ornelles, Douglas S Lyles

Open access · goldAbstract read
In one paragraph

Article in Molecular therapy oncolytics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Robert S BayneDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Shelby PuckettDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Lindsey Ulkus RodriguesDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Scott D CramerDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Jingyun LeeDepartment of Internal Medicine, Section on Molecular Medicine, Comprehensive Cancer Center, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Cristina M FurduiDepartment of Internal Medicine, Section on Molecular Medicine, Comprehensive Cancer Center, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Jeff W ChouDepartment of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Lance D MillerDepartment of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
David A OrnellesDepartment of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Douglas S LylesDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Wake Forest University · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
TRAINING PROGRAM IN IMMUNOLOGY AND PATHOGENESIST32AI007401 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Martha Ann Alexander-Miller · 1991 to 2026
$4.4M
RNA-Binding Proteins and Host Shut-Off by VSVR01AI105012 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI LYLES, DOUGLAS S. · 2014 to 2018
$2.2M
Mechanisms of Viral Resistance Mediated by MAP3K7 and CHD1 in Prostate CancerF30AI129321 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BAYNE, ROBERT · 2018 to 2020
$145k
NCI NIH HHS P30 CA012197NIAID NIH HHS F30 AI129321NIAID NIH HHS R01 AI105012NIAID NIH HHS T32 AI007401
6 · The paper itself

Abstract

A key principle of oncolytic viral therapy is that many cancers develop defects in their antiviral responses, making them more susceptible to virus infection. However, some cancers display resistance to viral infection. Many of these resistant cancers constitutively express interferon-stimulated genes (ISGs). The goal of these experiments was to determine the role of two tumor suppressor genes,

Indexed as

CHD1interferon-stimulated genesMAP3K7Oncolytic VirusProstate cancervesicular stomatitis virus

Identifiers

PMID32529027
PMCPMC7276393
OpenAlexW3028490383

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.