Evidence map›Paper›PMID 32528945›Full record

ArticleFrontiers in bioengineering and biotechnology2020

Optimizing an Injectable Composite Oxygen-Generating System for Relieving Tissue Hypoxia.

Tai-En Hsieh, Sheng-Ju Lin, Li-Chi Chen, Chun-Chieh Chen, Po-Liang Lai, Chieh-Cheng Huang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

  1. Macrophage Dab1 Links Early Hypoxia to Adaptive Angiogenesis to Drive Peripheral Nerve Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. Autonomous Implants.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Tai-En HsiehInstitute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan.
Sheng-Ju LinInstitute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan.
Li-Chi ChenInstitute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan.
Chun-Chieh ChenDepartment of Orthopaedic Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan City, Taiwan.
Po-Liang LaiDepartment of Orthopaedic Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan City, Taiwan.
Chieh-Cheng HuangInstitute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan.
National Tsing Hua University · TWLinkou Chang Gung Memorial Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxygen deficiency resulting from bone fracture-induced vascular disruption leads to massive cell death and delayed osteoblast differentiation, ultimately impairing new bone formation and fracture healing. Enhancing local tissue oxygenation can help promote bone regeneration. In this work, an injectable composite oxygen-generating system consisting of calcium peroxide (CaO

Indexed as

hypoxiahypoxia-inducible factoroxygen-generating biomaterialsperoxidePLGA microparticles

Identifiers

PMID32528945
PMCPMC7264163
OpenAlexW3030295514

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.