Evidence map›Paper›PMID 32528922›Full record

ArticleFrontiers in chemistry2020

Gold Nanoparticle-Enhanced and Roll-to-Roll Nanoimprinted LSPR Platform for Detecting Interleukin-10.

Seung Hee Baek, Hyun Woo Song, Sunwoong Lee, Jung-Eun Kim, Yeo Hyang Kim, Jung-Sub Wi, Jong G Ok, Jun Seok Park, Seonki Hong, Moon Kyu Kwak and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Seung Hee BaekDepartment of Molecular Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Hyun Woo SongDepartment of Mechanical Engineering, School of Mechanical Engineering, Kyungpook National University, Daegu, South Korea.
Sunwoong LeeDepartment of Molecular Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Jung-Eun KimDepartment of Molecular Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Yeo Hyang KimDepartment of Pediatrics, School of Medicine, Kyungpook National University, Daegu, South Korea.
Jung-Sub WiCenter for Nano-Bio Measurement, Korea Research Institute of Standards and Science, Daejeon, South Korea.
Jong G OkDepartment of Mechanical and Automotive Engineering, Seoul National University of Science and Technology, Seoul, South Korea.
Jun Seok ParkDepartment of Surgery, School of Medicine, Kyungpook National University, Daegu, South Korea.
Seonki HongDepartment of Emerging Materials Science, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, South Korea.
Moon Kyu KwakDepartment of Mechanical Engineering, School of Mechanical Engineering, Kyungpook National University, Daegu, South Korea.
Hye Jin LeeDepartment of Chemistry and Green Nano Materials Research Center, Kyungpook National University, Daegu, South Korea.
Sung-Wook NamDepartment of Molecular Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Kyungpook National University · KRDaegu Gyeongbuk Institute of Science and Technology · KRKorea Research Institute of Standards and Science · KRSeoul National University of Science and Technology · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Localized surface plasmon resonance (LSPR) is a powerful platform for detecting biomolecules including proteins, nucleotides, and vesicles. Here, we report a colloidal gold (Au) nanoparticle-based assay that enhances the LSPR signal of nanoimprinted Au strips. The binding of the colloidal Au nanoparticle on the Au strip causes a red-shift of the LSPR extinction peak, enabling the detection of interleukin-10 (IL-10) cytokine. For LSPR sensor fabrication, we employed a roll-to-roll nanoimprinting process to create nanograting structures on polyethylene terephthalate (PET) film. By the angled deposition of Au on the PET film, we demonstrated a double-bent Au structure with a strong LSPR extinction peak at ~760 nm. Using the Au LSPR sensor, we developed an enzyme-linked immunosorbent assay (ELISA) protocol by forming a sandwich structure of IL-10 capture antibody/IL-10/IL-10 detection antibody. To enhance the LSPR signal, we introduced colloidal Au nanocube (AuNC) to be cross-linked with IL-10 detection antibody for immunogold assay. Using IL-10 as a model protein, we successfully achieved nanomolar sensitivity. We confirmed that the shift of the extinction peak was improved by 450% due to plasmon coupling between AuNC and Au strip. We expect that the AuNC-assisted LSPR sensor platform can be utilized as a diagnostic tool by providing convenient and fast detection of the LSPR signal.

Indexed as

Au LSPR stripAu nanocubeIL-10nanoarchitectureroll-to-roll

Identifiers

PMID32528922
PMCPMC7264386
OpenAlexW3028646840

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.