Evidence map›Paper›PMID 32528898›Full record

ArticleFrontiers in oncology2020

Patient Derived Xenografts Expand Human Primary Pancreatic Tumor Tissue Availability for

Rebecca M Brock, Natalie Beitel-White, Sheryl Coutermarsh-Ott, Douglas J Grider, Melvin F Lorenzo, Veronica M Ringel-Scaia, Navid Manuchehrabadi, Robert C G Martin, Rafael V Davalos, Irving C Allen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Histotripsy Ablation in Preclinical Animal Models of Cancer and Spontaneous Tumors in Veterinary Patients: A Review.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022
    Review
  13. Review
  14. Article
  15. Histotripsy for the Treatment of Cholangiocarcinoma Liver Tumors: In Vivo Feasibility and Ex Vivo Dosimetry Study.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021
    Article
  16. Article
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Rebecca M BrockGraduate Program in Translational Biology, Medicine and Health, Virginia Polytechnic Institute and State University, Roanoke, VA, United States.
Natalie Beitel-WhiteDepartment of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States.
Sheryl Coutermarsh-OttDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, United States.
Douglas J GriderDepartment of Basic Science Education, Virginia Tech Carilion School of Medicine, Virginia Polytechnic Institute and State University, Roanoke, VA, United States.
Melvin F LorenzoDepartment of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States.
Veronica M Ringel-ScaiaGraduate Program in Translational Biology, Medicine and Health, Virginia Polytechnic Institute and State University, Roanoke, VA, United States.
Navid ManuchehrabadiResearch and Development, AngioDynamics, Marlborough, MD, United States.
Robert C G MartinDivision of Surgical Oncology, Department of Surgery, School of Medicine, University of Louisville, Louisville, KY, United States.
Rafael V DavalosDepartment of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States.
Irving C AllenGraduate Program in Translational Biology, Medicine and Health, Virginia Polytechnic Institute and State University, Roanoke, VA, United States.
Virginia Tech · USVirginia–Maryland College of Veterinary Medicine · USAngioDynamics (United States) · USUniversity of Louisville · US

Funding

Employing Novel Porcine Models of Orthotopic Pancreatic Cancer to Evaluate Histotripsy Based Tumor Ablation StrategiesR21EB028429 · NIBIB · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI ALLEN, IRVING C · 2019 to 2020
$428k
NIBIB NIH HHS R21 EB028429
6 · The paper itself

Abstract

New methods of tumor ablation have shown exciting efficacy in pre-clinical models but often demonstrate limited success in the clinic. Due to a lack of quality or quantity in primary malignant tissue specimens, therapeutic development and optimization studies are typically conducted on healthy tissue or cell-line derived rodent tumors that don't allow for high resolution modeling of mechanical, chemical, and biological properties. These surrogates do not accurately recapitulate many critical components of the tumor microenvironment that can impact

Indexed as

ablationconductivityinflammationIREirreversible electroporationpancreatic cancerPDX

Identifiers

PMID32528898
PMCPMC7257557
OpenAlexW3027893662

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.