Evidence map›Paper›PMID 32528832›Full record

ArticleActa pharmaceutica Sinica. B2020

Characterization of organic anion transporting polypeptide 1b2 knockout rats generated by CRISPR/Cas9: a novel model for drug transport and hyperbilirubinemia disease.

Xinrun Ma, Xuyang Shang, Xuan Qin, Jian Lu, Mingyao Liu, Xin Wang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 35 citations in OpenAlex.

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  7. Construction and characterization of a humanizedActa pharmaceutica Sinica. B · 2024
    Article
  8. Review
  9. Article
  10. Review
  11. Recent Advances in the Production of Genome-Edited Rats.International journal of molecular sciences · 2022
    Review
  12. Article
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  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xinrun MaShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Xuyang ShangShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Xuan QinShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Jian LuShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Mingyao LiuShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Xin WangShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
East China Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organic anion transporting polypeptide 1B1 and 1B3 (OATP1B1/3) as important uptake transporters play a fundamental role in the transportation of exogenous drugs and endogenous substances into cells. Rat OATP1B2, encoded by the

Indexed as

ADRs, adverse drug reactionsA/G, albumin/globulin ratioALB, albuminALP, alkaline phosphataseALT, alanine aminotransferaseAST, aspartate aminotransferaseAUC, the area under the time–plasma concentration curveBUN, blood urea nitrogenChr, chromosomeCL/F, clearance/bioavailabilityCmax, peak concentrationCRISPR/Cas9CRISPR, clustered regularly interspaced short palindromic repeatsCR, reatininecrRNA, mature CRISPR RNADAB, 3,3′-diaminobenzidineDBL, direct bilirubinDDI, drug–drug interactionDMSO, dimethyl sulfoxideFDA, the U.S. Food and Drug AdministrationGAPDH, glyceraldehyde 3-phosphate dehydrogenaseGLB, globulinGLU, glucoseHCG, human chorionic gonadotropinHDL-C, high density lipoprotein cholesterolHE, haemotoxylin and eosinHMG, hydroxymethylglutarylHRP, horseradish peroxidaseHZ, heterozygousIBIL, indirect bilirubinIS, internal standard solutionKO, knockoutLDL-C, low density lipoprotein cholesterolMC, methylcelluloseMRT, mean residence timeNC, nitrocelluloseOATP1B1/3OATP1B1/3, organic anion transporting polypeptide 1B1 and 1B3OATP1B2OATPs, organic anion transporting polypeptidesPAM, protospacer adjacent motifPMSG, pregnant mare serum gonadotropinp.o., peroralRat modelR-GT, γ-glutamyltranspeptidaseSDS-PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresisSD, Sprague–DawleysgRNA, single guide RNASLC, solute carrierSNPs, single nucleotide polymorphismsT7E I, T7 endonuclease ITALEN, transcription activator-like effector nucleaseTBA, total bile acidTBL, total bilirubinTBST, Tris-buffered saline Tween 20T-CH, total cholesterolTG, triglycerideTmax, peak timeTP, total proteinTransporterUA, uric acidUgt1a1, UDP glucuronosyltransferase family 1 member A1Vd/F, the apparent volume of distribution/bioavailabilityWT, wild typeZFN, zinc-finger nucleases

Identifiers

PMID32528832
PMCPMC7276679
OpenAlexW2989331970

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.