Evidence map›Paper›PMID 32528726›Full record

ArticleNPJ genomic medicine2020

Persistent

Christopher S Hong, Juan C Vasquez, Adam J Kundishora, Aladine A Elsamadicy, Jason M Beckta, Amrita Sule, Asher M Marks, Nalin Leelatian, Anita Huttner, Ranjit S Bindra and 3 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in NPJ genomic medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Cohesin mutations and chromatin changes in cancer.International journal of cancer · 2026
    Review
  2. Review
  3. Role of chromosomal cohesion and separation in aneuploidy and tumorigenesis.Cellular and molecular life sciences : CMLS · 2024
    Review
  4. Cohesin Mutations in Cancer: Emerging Therapeutic Targets.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Christopher S HongDepartment of Neurosurgery, Yale School of Medicine, New Haven, CT 06511 USA.
Juan C VasquezDepartment of Pediatrics, Yale School of Medicine, New Haven, CT 06511 USA.
Adam J KundishoraDepartment of Neurosurgery, Yale School of Medicine, New Haven, CT 06511 USA.ORCID 0000-0001-6419-7955
Aladine A ElsamadicyDepartment of Neurosurgery, Yale School of Medicine, New Haven, CT 06511 USA.
Jason M BecktaDepartment of Therapeutic Radiology, Yale School of Medicine, New Haven, CT 06511 USA.
Amrita SuleDepartment of Therapeutic Radiology, Yale School of Medicine, New Haven, CT 06511 USA.ORCID 0000-0001-6782-1899
Asher M MarksDepartment of Pediatrics, Yale School of Medicine, New Haven, CT 06511 USA.
Nalin LeelatianDepartment of Pathology, Yale School of Medicine, New Haven, CT 06511 USA.
Anita HuttnerDepartment of Pathology, Yale School of Medicine, New Haven, CT 06511 USA.
Ranjit S BindraDepartment of Therapeutic Radiology, Yale School of Medicine, New Haven, CT 06511 USA.
Michael L DiLunaDepartment of Neurosurgery, Yale School of Medicine, New Haven, CT 06511 USA.
Kristopher T KahleDepartment of Neurosurgery, Yale School of Medicine, New Haven, CT 06511 USA.ORCID 0000-0002-5922-7547
E Zeynep Erson-OmayDepartment of Neurosurgery, Yale School of Medicine, New Haven, CT 06511 USA.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
YALE CANCER CENTER CALABRESI IMMUNO-ONCOLOGY TRAINING PROGRAMK12CA215110 · NCI · YALE UNIVERSITY · PI Harriet M. Kluger · 2018 to 2026
$6.1M
NCATS NIH HHS UL1 TR001863NCI NIH HHS K12 CA215110
6 · The paper itself

Abstract

Similar to their adult counterparts, the prognosis for pediatric patients with high-grade gliomas remains poor. At time of recurrence, treatment options are limited and remain without consensus. This report describes the genetic findings, obtained from whole-exome sequencing of a pediatric patient with glioblastoma who underwent multiple surgical resections and treatment with standard chemoradiation, as well as a novel recombinant poliovirus vaccine therapy. Strikingly, despite the variety of treatments, there was persistence of a tumor clone, characterized by a deleterious

Indexed as

Cancer geneticsGenetics research

Identifiers

PMID32528726
PMCPMC7264170
OpenAlexW3030180357

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.