ArticleMicrosystems & nanoengineering2020
Novel diamond shuttle to deliver flexible neural probe with reduced tissue compression.
Article in Microsystems & nanoengineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Multi-Layer Brain-Mimicking Phantom for Replicating Dura and Pia Membrane Dimpling and Rupture Properties During Neural Interface Implantation.bioRxiv : the preprint server for biology · 2026Article
- Buckling-Resistant and Trace-Stacked (BRATS) Design Enables Aid-Free Implantation of Flexible Multielectrode Array with Minimized Inflammatory Tissue Response.Advanced functional materials · 2026Article
- Capturing the Electrical Activity of all Cortical Neurons: Are Solutions Within Reach?Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Biological and Mechanical Limitations for Chronic Fast-Scan Cyclic Voltammetry Sensor Design.Advanced materials technologies · 2025Article
- Foldable 3D opto-electro array for optogenetic neuromodulation and physiology recording.Microsystems & nanoengineering · 2025Article
- Flexible graphene-based neurotechnology for high-precision deep brain mapping and neuromodulation in Parkinsonian rats.Nature communications · 2025Article
- In vivo microelectrode arrays for neuroscience.Nature reviews. Methods primers · 2025Article
- An Experimental Study of Incremental Buckling-Resistant Inchworm-Type Insertion of Microwire Neural Electrodes.Journal of manufacturing science and engineering · 2024Article
- Flexible neural probes: a review of the current advantages, drawbacks, and future demands.Journal of Zhejiang University. Science. B · 2024Review
- Multiformity of extracellular microelectrode recordings from Aδ neurons in the dorsal root ganglia: a computational modeling study.Journal of neurophysiology · 2024Article
- Real-time in vivo thoracic spinal glutamate sensing during myocardial ischemia.American journal of physiology. Heart and circulatory physiology · 2023Article
- Structural and functional changes of deep layer pyramidal neurons surrounding microelectrode arrays implanted in rat motor cortex.Acta biomaterialia · 2023Article
- Translational opportunities and challenges of invasive electrodes for neural interfaces.Nature biomedical engineering · 2023Review
- Flexible multichannel electrodes for acute recording in nonhuman primates.Microsystems & nanoengineering · 2023Article
- Implantable intracortical microelectrodes: reviewing the present with a focus on the future.Microsystems & nanoengineering · 2023Review
- A mosquito mouthpart-like bionic neural probe.Microsystems & nanoengineering · 2023Article
- Research Progress on the Flexibility of an Implantable Neural Microelectrode.Micromachines · 2022Review
- The Future of Neuroscience: Flexible and Wireless Implantable Neural Electronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- A comparison of insertion methods for surgical placement of penetrating neural interfaces.Journal of neural engineering · 2021Review
- Hybrid Multisite Silicon Neural Probe with Integrated Flexible Connector for Interchangeable Packaging.Sensors (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The ability to deliver flexible biosensors through the toughest membranes of the central and peripheral nervous system is an important challenge in neuroscience and neural engineering. Bioelectronic devices implanted through dura mater and thick epineurium would ideally create minimal compression and acute damage as they reach the neurons of interest. We demonstrate that a three-dimensional diamond shuttle can be easily made with a vertical support to deliver ultra-compliant polymer microelectrodes (4.5-µm thick) through dura mater and thick epineurium. The diamond shuttle has 54% less cross-sectional area than an equivalently stiff silicon shuttle, which we simulated will result in a 37% reduction in blood vessel damage. We also discovered that higher frequency oscillation of the shuttle (200 Hz) significantly reduced tissue compression regardless of the insertion speed, while slow speeds also independently reduced tissue compression. Insertion and recording performance are demonstrated in rat and feline models, but the large design space of these tools are suitable for research in a variety of animal models and nervous system targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.