ArticleAnalytical methods : advancing methods and applications2019
Droplet Incubation and Splitting in Open Microfluidic Channels.
Article in Analytical methods : advancing methods and applications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- An open-source, modular optoelectrical sensor for on-chip flow characterization in droplet-based microfluidics.HardwareX · 2026Article
- On-Demand Droplet Routing and Splitting Using Independently Addressable Interdigitated Electrodes.Micromachines · 2026Article
- Open-Channel Droplet Microfluidic Platform for Passive Generation of Human Sperm Microdroplets.ACS biomaterials science & engineering · 2025Article
- Open-Channel Droplet Microfluidic Platform for Passive Generation of Human Sperm Microdroplets.bioRxiv : the preprint server for biology · 2024Article
- Enhanced capillary pumping using open-channel capillary trees with integrated paper pads.Physics of fluids (Woodbury, N.Y. : 1994) · 2023Article
- Flow Cytometry: The Next Revolution.Cells · 2023Review
- Interfacial tension driven open droplet microfluidics.Advanced materials interfaces · 2023Article
- Neural network execution using nicked DNA and microfluidics.PloS one · 2023Article
- Cell-Free Production Systems in Droplet Microfluidics.Advances in biochemical engineering/biotechnology · 2023Review
- Methods to spontaneously generate three dimensionally arrayed microdroplets triggered by capillarity for bioassays and bioengineering.Biophysics and physicobiology · 2023Article
- Fungi-on-a-Chip: microfluidic platforms for single-cell studies on fungi.FEMS microbiology reviews · 2022Review
- Investigation of Solvent-Assisted In-Mold Bonding of Cyclic Olefin Copolymer (COC) Microfluidic Chips.Micromachines · 2022Article
- Recent progress of microfluidic chips in immunoassay.Frontiers in bioengineering and biotechnology · 2022Review
- Passive micropumping in microfluidics for point-of-care testing.Biomicrofluidics · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Droplet-based microfluidics enables compartmentalization and controlled manipulation of small volumes. Open microfluidics provides increased accessibility, adaptability, and ease of manufacturing compared to closed microfluidic platforms. Here, we begin to build a toolbox for the emerging field of open channel droplet-based microfluidics, combining the ease of use associated with open microfluidic platforms with the benefits of compartmentalization afforded by droplet-based microfluidics. We develop fundamental microfluidic features to control droplets flowing in an immiscible carrier fluid within open microfluidic systems. Our systems use capillary flow to move droplets and carrier fluid through open channels and are easily fabricated through 3D printing, micromilling, or injection molding; further, droplet generation can be accomplished by simply pipetting an aqueous droplet into an empty open channel. We demonstrate on-chip incubation of multiple droplets within an open channel and subsequent transport (using an immiscible carrier phase) for downstream experimentation. We also present a method for tunable droplet splitting in open channels driven by capillary flow. Additional future applications of our toolbox for droplet manipulation in open channels include cell culture and analysis, on-chip microscale reactions, and reagent delivery.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.