Evidence map›Paper›PMID 32528475›Full record

ArticleFrontiers in immunology2020

Hepatic Surgical Stress Promotes Systemic Immunothrombosis That Results in Distant Organ Injury.

Hongji Zhang, Julie Goswami, Patrick Varley, Dirk J van der Windt, Jinghua Ren, Patricia Loughran, Hamza Yazdani, Matthew D Neal, Richard L Simmons, Jinxiang Zhang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 42 citations in OpenAlex.

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  6. Beyond a Biomarker: Investigations of a Proinflammatory Role for Cell-Free DNA in Liver Transplant Ischemia and Reperfusion.Transplant international : official journal of the European Society for Organ Transplantation · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Hongji ZhangDepartment of Surgery, Wexner Medical Center, The Ohio State University, Columbus, OH, United States.
Julie GoswamiDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
Patrick VarleyDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
Dirk J van der WindtDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
Jinghua RenDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
Patricia LoughranDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
Hamza YazdaniDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
Matthew D NealDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
Richard L SimmonsDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
Jinxiang ZhangDepartment of Surgery, Union Hospital, Huazhong University of Science and Technology, Wuhan, China.
Allan TsungDepartment of Surgery, Wexner Medical Center, The Ohio State University, Columbus, OH, United States.
Hai HuangDepartment of Surgery, Wexner Medical Center, The Ohio State University, Columbus, OH, United States.
University of Pittsburgh Medical Center · USThe Ohio State University Wexner Medical Center · USHuazhong University of Science and Technology · CNUnion Hospital · CNWuhan Union Hospital · CN

Funding

Mechanistic Elucidation and Targeted Therapy of Platelet Dysfunction After TraumaR35GM119526 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEAL, MATTHEW D · 2016 to 2025
$3.9M
Surgery triggered immune response and liver metastasesR01CA214865 · NCI · UNIVERSITY OF VIRGINIA · PI Allan Tsung · 2018 to 2026
$3.4M
Endogenous regulators of inflammation in liver ischemia/reperfusionR01GM095566 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TSUNG, ALLAN · 2011 to 2019
$2.7M
NCI NIH HHS R01 CA214865NIGMS NIH HHS R01 GM095566NIGMS NIH HHS R35 GM119526
6 · The paper itself

Abstract

Innate immunity can initiate platelet activation during the development of thrombosis through a process, termed immunothrombosis. Neutrophils form neutrophil extracellular traps (NETs) that have been shown to interact directly with platelets and play pro-coagulant roles in a variety of infectious and sterile inflammatory settings. Hepatic surgical stress initiated by ischemia/reperfusion (I/R) injury has wide systemic consequences on distant organs. However, the mechanisms of this remote injury phenomenon are not well-understood. Here, we sought to determine the role of NETs in causing systemic immunothrombosis and distant organ injury following a local inflammatory insult with liver I/R. Postoperative thromboelastographic revealed that the speed of clot formation (alpha-angle) was significantly increased whereas time to clot formation (R-time) were decreased by in patients undergoing liver resection, indicating a hypercoagulable state after surgery. In mice subjected to liver I/R, circulating platelet activation and platelet-neutrophil aggregates were significantly increased. Injured distant organs such as the lung and kidney displayed NETs and platelet-rich micro-thrombi in the microvasculature following liver I/R. The immune-thrombi and organ damage were dramatically decreased when NETs were inhibited by DNase treatment. Depletion of

Indexed as

Blood CoagulationPlatelet ActivationAdolescentAdultAgedAged, 80 and overAnimalsBlood PlateletsCase-Control StudiesChildChild, PreschoolDisease Models, AnimalExtracellular TrapsFemaleHepatectomyHumanspeptidylarginine deiminase 4, mouseProtein-Arginine Deiminase Type 4Tlr4 protein, mouseToll-Like Receptor 4immunothrombosisliver sterile inflammationneutrophil extracellular trapsplateletssurgical stress

Identifiers

PMID32528475
PMCPMC7256968
OpenAlexW3026148210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.